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Figure 2 | BMC Genomics

Figure 2

From: Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing

Figure 2

Analysis of affected hematological genes in Rpl11-deficient zebrafish embryos at 48 hpf. A, Cluster analysis of affected hematological genes. A total of 33 hematological genes exhibited changed expression in Rpl11-deficient zebrafish embryos at 48 hpf (FC >1.5, p-value <0.05). Hematological genes were clustered in upregulated and downregulated groups, and most affected hematopoietic genes were downregulated in Rpl11-deficient zebrafish embryos at 48 hpf; B, Gene ontology (GO) enrichment of affected hematological genes in Rpl11-deficient zebrafish embryos at 48 hpf. Among hematological genes, the largest three fractions represented oxidoreductase activity, cytoplasmic component, and electron carrier activity. Hematological genes with iron metabolism-associated functions such as heme and iron binding were also enriched.

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