Table 1 The most significantly affected canonical pathways found in LESCs
Ingenuity canonical pathways | -Log(B-H-P-value) | Ratio | |
|---|---|---|---|
Top canonical pathways | Hepatic fibrosis/hepatic stellate cell activation | 8.36E-05 | 32/142 (0.225) |
Inhibition of angiogenesis by TSP1 | 2.22E-04 | 12/34 (0.353) | |
RAR activation | 5.01E-04 | 35/179 (0.196) | |
Antigen presentation pathway | 1.25E-03 | 11/40 (0.275) | |
Axonal guidance signaling | 1.31E-03 | 65/432 (0.15) | |
Top tox (toxicological) pathways | Hepatic fibrosis | 4.25E-06 | 27/93 (0.29) |
Glutathione depletion - cyp induction and reactive metabolites | 6.6E-05 | 7/12 (0.583) | |
Liver proliferation | 1.5E-04 | 39/189 (0.206) | |
Persistent renal ischemia-Reperfusion injury (mouse) | 4.41E-04 | 10/30 (0.333) | |
Increases renal proliferation | 4.54E-04 | 24/101 (0.238) |