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Table 3 Top 20 up- and down-regulated custom selected genes in LESC

From: Comparison of upstream regulators in human ex vivo cultured cornea limbal epithelial stem cells and differentiated corneal epithelial cells

Symbol

Entrez gene name

Fold change

Activation z-score

p-value of overlap

Molecule type

Fold change up-regulated

FN1

Fibronectin 1

74.934

2.979

8.37E-05

Enzyme

CCNA1

Cyclin A1

27.199

 

3.42E-02

Other

IL1B

Interleukin 1, beta

24.948

4.924

8.09E-15

Cytokine

INHBA

Inhibin, beta A

21.815

1.352

2.27E-04

Growth factor

SERPINE1

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

18.854

−0.927

1.40E-02

Other

GDF15

Growth differentiation factor 15

16.924

1.999

2.63E-02

Growth factor

PTHLH

Parathyroid hormone-like hormone

16.2

1.972

8.72E-03

Other

OSMR

Oncostatin M receptor

15.366

1.982

1.83E-02

Transmembrane receptor

CXCL10

Chemokine (C-X-C motif) ligand 10

15.171

0.911

2.31E-02

Cytokine

MMP9

Matrix metallopeptidase 9 (gelatinase B, 92 kDa type IV collagenase)

14.243

0.689

1.72E-02

Peptidase

IL1R1

interleukin 1 receptor, type I

13.972

2.603

5.76E-03

Transmembrane receptor

MMP1

Matrix metallopeptidase 1 (interstitial collagenase)

13.875

1.188

4.01E-03

Peptidase

ICAM1

Intercellular adhesion molecule 1

13.681

2.961

1.36E-03

Transmembrane receptor

ITGA5

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

13.455

2.411

1.46E-02

Other

SH3KBP1

SH3-domain kinase binding protein 1

12.752

 

4.98E-02

Other

AKT3

V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

11.843

 

4.76E-02

Kinase

LOXL2

Lysyl oxidase-like 2

11.734

1.992

1.88E-03

Enzyme

CEACAM5

Carcinoembryonic antigen-related cell adhesion molecule 5

10.588

 

1.23E-02

Other

SLPI

Secretory leukocyte peptidase inhibitor

8.53

−2.433

1.06E-02

Other

PDZK1IP1

PDZK1 interacting protein 1

8.485

 

1.23E-02

Other

Fold change down-regulated

CRTAC1 -

Cartilage acidic protein 1

−72.277

   

LPA

Lipoprotein, Lp(a)

−11,623

 

4.98E-02

Other

ETV1

Ets variant gene 1

−7,444

1.969

1.83E-02

Transcription regulator

EDNRB

Endothelin receptor type B

−7,25

 

3.38E-02

G-protein coupled receptor

BMP7

Bone morphogenetic protein 7

−6,436

0.733

1.17E-04

Growth factor

NREP

Neuronal regeneration related protein

−5,823

−0.248

3.81E-03

Other

CFTR

Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

−5,766

−1.993

1.49E-01

Ion channel

DCN

Decorin

−5,066

0.172

6.04E-07

Other

RORA

RAR-related orphan receptor alpha

−4,781

−0.439

2.61E-03

Ligand-dependent nuclear receptor

LEF1

Lymphoid enhancer binding factor 1

−4,441

−0.306

2.01E-02

Transcription regulator

BDKRB1

Bradykinin receptor B1

−4,1

−2.000

6.89E-04

G-protein coupled receptor

GJA1

Gap junction protein, alpha 1

−3,94

−1.480

5.54E-04

Transporter

FAM3B

Family with sequence similarity 3, member B

−3,9

 

3.20E-08

Cytokine

P2RX7

Purinergic receptor P2X, ligand-gated ion channel, 7

−3,885

 

1.15E-02

Ion channel

KAT2B

K(lysine) acetyltransferase 2B

−3,829

1.963

8.27E-02

Transcription regulator

ODC1

Ornithine decarboxylase, structural 1

−3,63

 

4.98E-02

Enzyme

EPHX2

Epoxide hydrolase 2, cytoplasm

−3,469

 

3.42E-02

Enzyme

MAT1A

Methionine adenosyltransferase I, alpha

−3,386

−0.215

1.82E-02

Enzyme

CTSL2

Cathepsin L2

−3,385

 

4.98E-02

Peptidase

DUSP1

Dual specificity phosphatase 1

−3,358

−1.881

6.12E-02

Phosphatase

NOV

Nephroblastoma overexpressed

−3,149

0.555

1.94E-02

Growth factor

  1. The top 20 up and down regulated genes in LESCs as determined by the IPA software.