Figure 4

The network of proteins interacting with PAR-2 and PAR-3 in Caenorhabditis elegans and their orthologues in Romanomermis culicivorax and Trichinella spiralis . The network cartoon is based on the core polarity pathway extracted from WormBase, derived from both genetic and physical interactions. PAR-2 was missing from the dorylaim nematodes, as were the directly connected MES-3 and MES-4 genes. The R. culicivorax PAR-3-like protein was not retrieved as an orthologue of C. elegans and T. spiralis PAR-3 proteins, but was identified employing sensitive sequence similarity search. See Table 3 for additional proteins interacting with PAR proteins and their presence-absence patterns.