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Table 2 Loci preferentially expressed in 4 or more strains in FeHm-restricted conditions

From: Comparison of transcription of the Haemophilus influenzae iron/heme modulon genes in vitro and in vivo in the chinchilla middle ear

  

Fold changec

Locusa

Descriptionb

R2866

10810

Rd

R2846

86-028NP

HI0035

Conserved hypothetical protein/predicted transporter

-2.46

-1.74

-1.55

-2.16

-1.19

HI0075

Anaerobic ribonucleoside-triphosphate reductase, alpha subunit NrdD

-2.95

-2.54

-4.03

-2.34

-1.66

HI0095

Putative methyltransferase

-12.56

-3.93

-10.21

-2.15

-3.47

HI0097

Iron (III) ABC transporter, periplasmic binding protein HitA

-14.27

-4.52

-8.15

-2.39

-2.38

HI0098

Iron (III) ABC transporter, permease protein HitB

-1.80

-2.70

-3.55

-2.33

-2.24

HI0099

Iron (III) ABC transporter, ATP-binding protein HitC

-2.01

-2.16

-3.56

-2.19

-2.03

HI0113

Probable TonB-dependent heme receptor HemR

-4.72

-2.28

-2.36

-3.39

-1.64

HI0153

Putative anaerobic C4-dicarboxylate transporter

-2.70

-2.24

not ond

-2.00

-1.54

HI0251

Protein TonB

-1.99

-1.69

-2.75

-1.42

-1.40

HI0252

Biopolymer transport ExbD

-2.45

-1.87

-3.02

-1.54

-1.76

HI0253

Biopolymer transport protein ExbB

-3.07

-2.26

-2.69

-1.64

-1.84

HI0262

Heme-hemopexin utilization protein HxuC

-24.69

-4.03

-10.30

-3.95

-2.64

HI0263

Heme-hemopexin utilization protein HxuB

-29.31

-3.29

-9.20

-2.92

-3.93

HI0264

Heme-hemopexin utilization protein HxuA

-18.55

-2.86

-7.44

-2.55

-2.11

HI0359

Fe/Mn/Zn ABC transporter, permease protein YfeD

-2.92

ns

-4.35

-1.31

-1.66

HI0360

Fe/Mn/Zn ABC transporter, permease protein YfeC

-3.54

ns

-6.90

-1.34

-1.81

HI0361

Fe/Mn/Zn ABC transporter, ATP-binding protein YfeB

-7.89

ns

-8.91

-1.74

-2.12

HI0362

Fe/Mn/Zn ABC transporter, periplasmic binding protein YfeA

-6.01

-1.17

-11.74

-1.57

-1.78

HI0534

Aspartate-ammonia lyase AspA

-1.56

-3.38

-3.12

-2.62

-1.67

HI0584

Putative peptidase/hydrolase

-1.84

-1.59

-1.69

-1.75

ns

HI0661

Hemoglobin-haptoglobin binding protein HgpB

-6.52

-4.14

-1.20

-2.51

-3.09

HI0691

Glycerol kinase GlpK

-5.71

-3.40

-1.61

-1.58

ns

HI0712

Hemoglobin-haptoglobin binding protein HgpC

-9.82

-2.94

-6.64

-2.02

ns

HI0809

Phosphoenolpyruvate carboxykinase PckA

-6.41

-3.16

-2.87

-1.92

-1.35

HI0994

Transferrin-binding protein Tbp1

-9.56

-8.16

-12.40

-8.43

-3.15

HI0995

Transferrin-binding protein Tbp2

-19.45

-16.53

-13.94

-8.57

-6.92

HI0997m

Putative outer membrane protein OmpU

-15.68

-14.61

not ond

-9.24

-7.44

HI1210

Malate dehydrogenase Mdh

-5.29

-2.68

-2.47

-1.97

-1.49

HI1356

4-alpha-glucanotransferase (amylomaltase) MalQ

-2.32

-2.25

-1.82

-2.29

-1.76

HI1357

1,4-alpha-gulcan branching enzyme GlgB

-2.75

-2.67

-1.59

-2.44

-1.65

HI1358

Glycogen debranching enzyme GlgX

-2.38

-2.80

-1.51

-2.35

-1.48

HI1359

Glucose-1-phosphate adenyltransferase GlgC

-3.28

-3.10

-1.73

-2.32

-1.44

HI1360

Glycogen synthase GlgA

-2.03

-2.56

-1.52

-2.03

ns

HI1369

Probable TonB-dependent transporter

-10.65

-1.56

-7.02

-8.04

-1.70

HI1427

Putative ABC transport, periplasmic binding protein

-6.60

-2.32

-6.12

-2.65

-1.52

  1. aGene locus in Rd KW20.
  2. bName and description of the gene based upon annotation of Rd KW20 or R2846 and R2866.
  3. cFold change as determined from the microarray data. Numbers in italics are below the 1.5 fold threshold but have a p-value below the statistically significant threshold. Numbers in bold are above the 1.5 fold threshold but have a p-value above the statistically significant threshold. ns = non significant and below 1.5-fold threshold.
  4. dlocus not included on the Rd KW20 array but expression determined to be above 2 fold change in expression by Q-PCR.