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Table 2 Loci preferentially expressed in 4 or more strains in FeHm-restricted conditions

From: Comparison of transcription of the Haemophilus influenzae iron/heme modulon genes in vitro and in vivo in the chinchilla middle ear

   Fold changec
Locusa Descriptionb R2866 10810 Rd R2846 86-028NP
HI0035 Conserved hypothetical protein/predicted transporter -2.46 -1.74 -1.55 -2.16 -1.19
HI0075 Anaerobic ribonucleoside-triphosphate reductase, alpha subunit NrdD -2.95 -2.54 -4.03 -2.34 -1.66
HI0095 Putative methyltransferase -12.56 -3.93 -10.21 -2.15 -3.47
HI0097 Iron (III) ABC transporter, periplasmic binding protein HitA -14.27 -4.52 -8.15 -2.39 -2.38
HI0098 Iron (III) ABC transporter, permease protein HitB -1.80 -2.70 -3.55 -2.33 -2.24
HI0099 Iron (III) ABC transporter, ATP-binding protein HitC -2.01 -2.16 -3.56 -2.19 -2.03
HI0113 Probable TonB-dependent heme receptor HemR -4.72 -2.28 -2.36 -3.39 -1.64
HI0153 Putative anaerobic C4-dicarboxylate transporter -2.70 -2.24 not ond -2.00 -1.54
HI0251 Protein TonB -1.99 -1.69 -2.75 -1.42 -1.40
HI0252 Biopolymer transport ExbD -2.45 -1.87 -3.02 -1.54 -1.76
HI0253 Biopolymer transport protein ExbB -3.07 -2.26 -2.69 -1.64 -1.84
HI0262 Heme-hemopexin utilization protein HxuC -24.69 -4.03 -10.30 -3.95 -2.64
HI0263 Heme-hemopexin utilization protein HxuB -29.31 -3.29 -9.20 -2.92 -3.93
HI0264 Heme-hemopexin utilization protein HxuA -18.55 -2.86 -7.44 -2.55 -2.11
HI0359 Fe/Mn/Zn ABC transporter, permease protein YfeD -2.92 ns -4.35 -1.31 -1.66
HI0360 Fe/Mn/Zn ABC transporter, permease protein YfeC -3.54 ns -6.90 -1.34 -1.81
HI0361 Fe/Mn/Zn ABC transporter, ATP-binding protein YfeB -7.89 ns -8.91 -1.74 -2.12
HI0362 Fe/Mn/Zn ABC transporter, periplasmic binding protein YfeA -6.01 -1.17 -11.74 -1.57 -1.78
HI0534 Aspartate-ammonia lyase AspA -1.56 -3.38 -3.12 -2.62 -1.67
HI0584 Putative peptidase/hydrolase -1.84 -1.59 -1.69 -1.75 ns
HI0661 Hemoglobin-haptoglobin binding protein HgpB -6.52 -4.14 -1.20 -2.51 -3.09
HI0691 Glycerol kinase GlpK -5.71 -3.40 -1.61 -1.58 ns
HI0712 Hemoglobin-haptoglobin binding protein HgpC -9.82 -2.94 -6.64 -2.02 ns
HI0809 Phosphoenolpyruvate carboxykinase PckA -6.41 -3.16 -2.87 -1.92 -1.35
HI0994 Transferrin-binding protein Tbp1 -9.56 -8.16 -12.40 -8.43 -3.15
HI0995 Transferrin-binding protein Tbp2 -19.45 -16.53 -13.94 -8.57 -6.92
HI0997m Putative outer membrane protein OmpU -15.68 -14.61 not ond -9.24 -7.44
HI1210 Malate dehydrogenase Mdh -5.29 -2.68 -2.47 -1.97 -1.49
HI1356 4-alpha-glucanotransferase (amylomaltase) MalQ -2.32 -2.25 -1.82 -2.29 -1.76
HI1357 1,4-alpha-gulcan branching enzyme GlgB -2.75 -2.67 -1.59 -2.44 -1.65
HI1358 Glycogen debranching enzyme GlgX -2.38 -2.80 -1.51 -2.35 -1.48
HI1359 Glucose-1-phosphate adenyltransferase GlgC -3.28 -3.10 -1.73 -2.32 -1.44
HI1360 Glycogen synthase GlgA -2.03 -2.56 -1.52 -2.03 ns
HI1369 Probable TonB-dependent transporter -10.65 -1.56 -7.02 -8.04 -1.70
HI1427 Putative ABC transport, periplasmic binding protein -6.60 -2.32 -6.12 -2.65 -1.52
  1. aGene locus in Rd KW20.
  2. bName and description of the gene based upon annotation of Rd KW20 or R2846 and R2866.
  3. cFold change as determined from the microarray data. Numbers in italics are below the 1.5 fold threshold but have a p-value below the statistically significant threshold. Numbers in bold are above the 1.5 fold threshold but have a p-value above the statistically significant threshold. ns = non significant and below 1.5-fold threshold.
  4. dlocus not included on the Rd KW20 array but expression determined to be above 2 fold change in expression by Q-PCR.