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Table 1 The characterized fusion or splicing peptides identified from the MS/MS data.

From: Identification of gene fusions from human lung cancer mass spectrometry data

 

Peptide

Gene

No.

X!Tandem

No.

Omssa

  

Fusion

EQISENPTEATDIDFIR

PTPN12:HSP90AA1

5

9

A

D

Fusion

VIFMDGNGYISAAELR

HN1:CALM1

9

3

A

D

Fusion

IMGIPEEEQMVLSR

MYH9:ALK

4

5

A

D

Fusion

ENVGLEEEQQALQK

PDIA6:TPM2

3

6

A

D

Fusion

AVFVDLEPTVIGGGSVR

TUBA1C:PCGF2

5

3

A

D

Fusion

AAEDDEFTHLYTLIVRPDNTYEVK

GPR115:CALR

2

5

A

D

Fusion

EDSELLISSWLVTDR

DOCK9:BAZ1A

3

2

A

D

Fusion

AVQQELDDLLVDLDHQR

TGFBI:MYH9

2

2

A

D

Fusion

QVTNFLSSINEEITPR

FGFR1:BCR

1

2

A

D

Fusion

ERPAPGQAVLSGGTTMYPGIADR

ACO2:ACTB

1

2

A

D

Fusion

LSAASTWLEDEGVGATTVLFK

HYOU1:HMGA1

1

1

A

D

Fusion

AVFVDLEPTVIEPVR

TUBA1A:PTPN13

1

1

A

D

Fusion

EAREVIELTK

CLCN3:SMNDC1

4

5

B

D

Fusion

NKAEILELAGNAAR

ATP2B4:H2AFY

3

3

B

D

Fusion

EAKGESGPSGPAGPTGAR

USP6:COL1A1

3

2

B

D

Fusion

GRTGDAGPVGEAGAAGPAGPAGPR

COL1A1:COL1A2

1

2

B

D

Fusion

AKQEPEVNGGSGDAVPSG

NEVSENMEEEEEALSLMK

NASP:WIPF1

1

2

B

D

Fusion

AHSEEPMEIFVDDETK

ESPN:BAT1

4

6

C

D

Fusion

TTGIVMDSGDGVTHTVPDASRVP

ACTB:GNAS

1

1

C

D

Splicing

INGGGGGSVPGIER

HNRNPM

12

0

A

 

Splicing

GDVEEDETIPDSPSVLETIR

TNPO1

2

6

A

D

Splicing

GGSGYGDLGGPIITTQVTIPK

HNRNPK

3

3

A

D

Splicing

RVEDEVNSGVGQDGSLLSSPFLK

SLC35A4

2

2

B

D

  1. The two genes in the fusion events are separated by colon. The value in the columns of No.X!Tandem and No.Omssa column are the number of spectra of the peptide. A indicates that the peptide was fully digested by trypsin and with no mis-cleavage. B indicates that the peptide was fully digested but with one mis-cleavage. C indicates that the peptide was semi-digested. D indicates that the peptide was identified by at least one same spectrum in both X!Tandem and Omssa search engines.