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Figure 6 | BMC Genomics

Figure 6

From: Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes

Figure 6

Cooperating TFs of p63. 13 TFs corresponding to 10 motifs (CEBPB, AP1(CFOS, FOSL2,JUND), BACH1, AP2(TFAP2C), STAT1, STAT3, MYCMAX (MAX, c-MYC), USF(USF2), RFX(RFX5), ELK1) were determined as potential cooperating TFs for p63. The characteristics that determine these TFs as potential cooperating TFs are: 1) enrichment of TF binding at p63 targets (P value <0.01 & overlap >5%) - as measured by ChIP-Seq from any available cell-line, 2) high expression in keratinocytes (RPKM >2) - as determined by RNA-Seq in NHEK cell-line, 3) enrichment of the TF’s motif at p63 targets (P value <0.01 & overlap >5%) and co-occurrence with p63 motif (P value <0.01). The TFs are sorted in descending order by an average percentage rank calculated across the different analysis.

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