Table 1 Annotating p63 targets clustered by chromatin profiles
Cluster | Size of cluster | Chromatin based segmentation | Median distance to nearest TSS | Median expression of nearest gene (RPKM) | Top GO terms (Biological Process) (Binomial FDR Q-val) | Top PANTHER pathways (Binomial FDR Q-val) |
|---|---|---|---|---|---|---|
A1 | 167 | Active Promoters | Proximal (898Â bp) | 8.09 | 1. Regulation of programmed cell-death (2.98e-2) | 1. P53 pathway (1.27e-3) |
A2 | 1309 | Strong Enhancers | Distal (35Â kb) | 5.03 | 1. Anti-apoptosis (8.28e-14) | 1. Apoptosis signaling pathway (1.94e-9) |
2. Hemi-desmosome assembly (1.166e-10) | 2. Integrin signaling pathway (1.67e-7) | |||||
3. Epidermis development (1.85e-9) | 3. Interleukin signaling pathway (1.1299e-6) | |||||
B1 | 2035 | Strong Enhancers | Distal (37Â kb) | 3.85 | 1. Epidermis development (3.29e-9) | 1. T cell activation (2.06e-4) |
2. Hair follicle development (3.25e-6) | Â | |||||
3. Hair cycle (3.88e-6) | ||||||
B2 | 3491 | Strong/weak enhancers | Distal (49.3Â kb) | 2.28 | 1. Response to mechanical stimulus (9.75e-10) | 1. T cell activation (1.9e-8) |
2. Negative regulation of intracellular protein kinase cascade (1.54e-6) | 2. VEGF signaling pathway (3.77e-5) | |||||
3. Response to reactive oxygen species (2.6e-6) | ||||||
B3 | 4630 | Repressed/Inactive | Distal (57.4Â kb) | 1.09 | Hair cycle (1.19e-9) | No term enriched |
Hair follicle development (1.56e-9) | ||||||
Cellular response to gonadotropin stimulus (4.16e-4) |