Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function

Table 5 Peptide diversity of the catshark pancreas, brain and liver

Peptide	Pancreas IHC	Pancreas transcriptome	Brain transcriptome	Liver transcriptome
Insulin	+	+	-	-
Glucagon	+	+	-	-
Somatostatin	+	+	+	-
Pancreatic polypeptide	+	-	-	-
Peptide YY	+	+	+	-
Gastrin-releasing peptide	+	+	+	-
Neuromedin U	+	+	+	+
Enkephalin	+	+	+	-
Cholecystokinin	+	-	+	-
Gastrin	+	-	-	-
Vasoactive intestinal polypeptide	+	+	+	-
Gastric inhibitory polypeptide	+	-	-	-
Secretin	+	-	-	-

Our comprehensive transcriptomic survey of the lesser spotted catshark pancreas highlights the disparity in the estimation of peptide diversity in early vertebrates as previously suggested by immunohistochemical (IHC) studies and highlights the similarity of pancreas and brain peptide complements.

ISSN: 1471-2164