Figure 4

Expression changes of apoptomirs between mutant and normal retinas at different ages. FC differences of apoptomirs as measured by qRT-PCR are shown at 3, 5, 7, 16 wks in xlpra2 and rcd1, as well as 6.4, 8.3-9.9, 11.9-14.1 wks in erd compared to normals. Selected apoptomirs belong to different functional groups: A) anti-apoptotic that were DE at later ages: miR-9, -19a, -20; B) anti-apoptotic that were DE during the course of disease: miR-21, -155, -221; C) pro-apoptotic: miR-122, -129; D) dual properties, anti- and pro-apoptotic: miR-29b, -146a. An asterisk indicates statistical significance (p < 0.05; FC > +/-2); bars show SD of biological triplicates. Results for miR-183 are not illustrated because they were not significant in any of the diseases and ages tested.