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Table 1 Common gene targets of all the up-regulated (FC > 5) miRNAs identified at 16 wks

From: Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration

Gene target symbol

Definition

NCBI accession sequences

FBXO28

F-box protein 28

NM_015176; AK303381

BBX

Bobby sox homolog (Drosophila)

NM_020235; NM_001142568

SPRED1

Sprouty-related, EVH1 domain-containing protein 1

NM_152594

MMAA

Methylmalonic aciduria (cobalamin deficiency) type A (mitochondrial)

NM_172250

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

NM_005668

KCNK10

potassium channel, subfamily K, member 10

NM_021161; NM_138317

USP9Y

Ubiquitin specific peptidase 9, Y-linked

NM_004654

ALG11

Asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (Yeast)

NM_001004127

DIEXF

Digestive organ expansion factor homolog (Zebrafish)

NM_014388; AK314061

RORA

RAR-related orphan receptor A

NM_002943; NM_134260

PHACTR2

Phosphatase and actin regulator 2

NM_014721; NM_001100164

SNTB2

Syntrophin, beta 2 (dystrophin-associated protein A1, 59 kDa, basic component 2)

NM_006750

BCAT1

Branched chain amino-acid transaminase 1, cytosolic

NM_005504; AK128527

PAG1

Phosphoprotein associated with glycosphingolipid microdomains 1

NM_018440

CREB1

cAMP responsive element binding protein 1

NM_004379; NM_134442

PTAR1

Protein prenyltransferase alpha subunit repeat containing 1

NM_001099666

TFCP2L1

Transcription factor CP2-like 1

NM_014553; AL137740

SLC1A2

Solute carrier family 1 (glial high affinity glutamate transporter), member 2

NM_004171; U01824

ACVR2B

Activin A receptor, type IIB

NM_001106; BC096245

ST8SIA3

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

NM_015879

UBN2

Ubinuclein 2

NM_173569

ADCY1

Adenylate cyclase 1 (brain)

NM_021116

DNAH14

Dynein, axonemal, heavy chain 14

NM_001373

SSR1

Signal sequence receptor, alpha

NM_003144; CR599599

FUT9

Fucosyltransferase 9 (alpha (1,3) fucosyltransferase)

NM_006581

SCAI

Suppressor of cancer cell invasion

NM_173690; NM_001144877

CDK6

Cyclin-dependent kinase 6

NM_001259; NM_001145306

TNRC6B

Trinucleotide repeat containing 6B

NM_015088; NM_001024843

LOC728264

Homo sapiens cDNA FLJ44517 fis, clone UTERU3002667

AK126481

CBX5

Chromobox homolog 5

NM_012117; NM_001127321

NSL1

Kinetochore-associated protein NSL1 homolog

NM_015471; AK303250

KSR2

Kinase suppressor of ras 2

NM_173598

NEAT1

Nuclear paraspeckle assembly transcript 1

NR_028272

SH3TC2

SH3 domain and tetratricopeptide repeats 2

NM_024577; AB075865

TSIX

X (inactive)-specific transcript, antisense

NR_003255

  1. The complete list of DE miRNAs identified at 16 wks between xlpra2 and normal retinas is shown in Additional file 3. The 35 common gene targets are reported with their symbols, definitions, and NCBI accession numbers.