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Table 1 Samples and known mutations

From: Target enrichment using parallel nanoliter quantitative PCR amplification

Samples

 

Mutations:

   

Name

Type

Gene name

Genomic location

cDNA position

Protein position

BT-549

Breast cancer cell line

PTEN

10:89720672

c.823delG

p.V275fs*1

CCRF-CEM

Leukemia cancer cell ine

CDKN2A

9:21968228

c.1_471del471

 
   

9:21971002

c.317_522del206

 
  

MLH1

3:37042536

c.298C > T

p.R100*

   

3:37056036

c.790 + 1G > A

 
  

NOTCH1

9:139399362

c.4783_4784ins36

p.R1595 > PRLPHNSSFHFLR

  

PTEN

10:89653782

c.80_492del413

 

HCT116

Colon cancer cell line

CDKN2A

9:21974758

c.68_69insG

p.R24fs*20

   

9:21994234

c.220_220delG

p.E74fs*15

  

MLH1

3:37056000

c.755C > A

p.S252*

IGROV-1

Ovarian cancer cell ine

MLH1

3:37070378

c.1513delA

p.S505fs*3

  

MSH6

2:48030647

c.3261delC

p.F1088fs*2

PC3

Prostate cancer cell line

PTEN

10:89685270

c.165_1212del1048

p.R55fs*1

SN12C

Kidney cancer cell line

NF2

22:30032739

c.115-1G > C

 

786-O

Kidney cancer cell line

CDKN2A

9:21974677

c.1_150del150

 
   

9:21984138-21984453

c.1_316del316

 
  

PTEN

10:89692961

c.445C > T

p.Q149*

  

VHL

3:10183842

c.311delG

p.G104fs*55

ACHN

Kidney cancer cell line

CDKN2A

9:21968228

c.1_471del471

 
   

9:21971002

c.317_522del206

 
  

NF2

22:30032794

c.169C > T

p.R57*

DU-145

Prostate cancer cell line

CDKN2A

9:21971108

c.250G > T

p.D84Y

  

MLH1

3:37038108

c.117-2A > T

 

HCT-15

Colon cancer cell line

APC

5:112177787

c.6496C > T

p.R2166*

   

5:112175539

c.4248delC

p.I1417fs*2

  

BRCA2

13:32913837

c.5351delA

p.N1784fs*7

   

13:32913837

c.3599_3600delGT

p.C1200fs*1

  

MSH6

2:48032121

c.3511_3516 > T

p.D1171fs*4

   

2:48025990

c.868delC

p.L290fs*1

HT-29

Colon cancer cell line

APC

5:112173848

c.2557G > T

p.E853*

   

5:112175957

c.4666_4667insA

p.T1556fs*3

MCF7

Breast cancer cell line

CDKN2A

9:21971002

c.317_522del206

 
   

9:21968228

c.1_471del471

 

MDA-MB-231

Breast cancer cell line

CDKN2A

9:21967751

c.1_522del522

 
   

9:21968228

c.1_471del471

 
  

NF2

22:30057209

c.691G > T

p.E231*

MOLT-4

Leukemia cancer cell line

CDKN2A

9:21967751

c.1_522del522

 
   

9:21968228

c.1_471del471

 
  

NOTCH1

9:139390649

c.7544_7545delCT

p.P2515fs*4

  

PTEN

10:89717775.

c.800delA

p.K267fs*9

OVCAR-5

Ovarian cancer cell line

CDKN2A

9:21967751

c.1_522del522

 
   

9:21968228

c.1_471del471

 

Normal1

Healthy normal1 control DNA

    

Normal2

Healthy normal2 control DNA

    
  1. NCI60 cell lines and normal control DNA samples included in this study with a list of known mutations per cel line.
  2. In nonsense or frameshift mutations the *symbol indicates the loss of the amino acid coding potential of the DNA sequence.