An overlapping set of genes is regulated by both NFIB and the glucocorticoid receptor during lung maturation

BMC Genomics

Table 5 Association of TF motifs with Nfib and Nr3c1 common targets

*Rank*	*Motif*	*Gene*	FC_{N f i b}	FC_{N r3c1}	p _{a c t}	p _{r e p}	MAS
1	AR_full	Ar	-	-	0.0013	0.97	2.86
2	TBR1_full	Tbr1	NA	-	0.0016	0.19	2.79
3	EBF1_full	Ebf1	-	-	0.0018	0.89	2.75
4	TBX2_full_2	Tbx2	-	-	0.0020	0.37	2.71
5	ZNF410_DBD	Zfp410	1.24	-	0.0025	0.90	2.60
6	NR3C2_DBD	Nr3c2	-	-	0.0036	0.82	2.44
7	Ar_DBD	Ar	-	-	0.0038	0.93	2.42
8	NR3C1_DBD	Nr3c1	-	*3.14	0.0042	0.84	2.38
9	TBX1_DBD	Tbx1	-	-	0.0048	0.01	2.32
10	AR_DBD	Ar	-	-	0.0054	0.75	2.26
11	EOMES_DBD	Eomes	NA	-	0.0057	0.14	2.24
12	NFIB_full	Nfib	*2.75	2.17	0.0060	0.13	2.22
...	...	...	...	...	...	...	...
732	ESRRB_DBD	Esrrb	NA	1.31	0.10	0.0071	-2.15
733	MEF2A_DBD	Mef2a	0.72	-	0.91	0.0060	-2.22
734	POU3F1_DBD_2	Pouf3f1	NA	NA	0.97	0.0050	-2.30
735	ESRRG_full_3	Esrrg	-	-	0.14	0.0038	-2.42
736	OTX1_DBD	Otx1	NA	NA	0.78	0.0036	-2.44
737	Esrra_DBD_2	Esrra	NA	NA	0.03	0.0008	-3.10
738	ESRRA_DBD	Esrra	NA	NA	0.13	0.0005	-3.26
739	FOXI1_full_2	Foxi1	NA	-	0.62	<10^-4	-4.01

The table shows the rank of the MAS score (rank), the motif name (motif), the associated gene name (gene), the expression fold-change (FC) of the gene in each KO, the (unadjusted) motif enrichment p-value in the activated set of genes (p_{a
c
t}), the (unadjusted) motif enrichment p-value in the repressed set of genes (p_{r
e
p}) and the motif association score (MAS). “NA” indicates that no expression data is available for the TF gene and “-” indicates that expression change is not significant (p-value >0.05). Motif names all in uppercase are for human TFs, others are for mouse TFs. *Note that these FC apply to the disrupted transcripts, and that no functional protein is produced for Nfib and Nr3c1.

ISSN: 1471-2164