Figure 1

Schematic of mapping and calling pipelines. Each box summarizes the data and data format used for each step of the human exome and microbiome mapping/calling pipelines. The pipeline begins with next-generation sequencing raw reads obtained from exome sequencing of saliva-derived DNA and ends in finalized exome variant calls and microbiome taxonomic abundances. Arrows indicate analysis methods used to process the human and saliva microbiome data (see Methods).