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Figure 2 | BMC Genomics

Figure 2

From: Perinatal bisphenol A exposure promotes dose-dependent alterations of the mouse methylome

Figure 2

Characterization of genome-wide methylation in BPA-exposed offspring. The genomic distributions of regions of altered methylation (RAMs), delineated as genome-wide or within promoter regions, from the edgeR analysis with p-value & 0.05 are displayed. (A) The bar graph identifies the number of RAMs in genome-wide scale. (B) The Venn diagram displays the overlap of RAMs among control (Ctr), 50 μg (UG) and 50 mg (MG) diet groups. (C) The bar graph and (D) Venn diagram of RAMs within promoter regions is displayed. (E) For each exposure comparison and for the full M-NGS library, pie charts display the proportion of RAMs in number of windows at CpG islands (CGIs), CpG shores, CpG shelves, and the remainder of the genome. In the Ctr vs. MG and in the UG vs. MG comparisons, approximately half of the RAMs occur in CpG shores (0-2 kb from CGIs). (F) The genomic distributions of RAMs (p-value & 0.05) at 5′UTRs, TSSs, CDSs, and 3′UTRs are delineated in bar graphs. The percentage of RAMs at CDS exons in the Ctr vs. UG comparison is decreased by more than half compared to other group comparisons. At the TSSs, the percentage of RAMs is comparable among the three group comparisons.

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