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Table 4 GO enrichment classification of alternatively spliced genes after hypoxia

From: Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells

Pathways

Gene symbol

Accession number

Splicing Index

Probe location

Gene description

Apoptosis-associated

     

Induction of apoptosis by intracellular signals

SART1

NM_005146

0.46

Exon11

Squamous cell carcinoma antigen recognized by T cells

Positive regulation of neuron apoptosis

PTPRF

NM_002840

2.56

Exon34

Protein tyrosine phosphatase, receptor type, F

Apoptosis

PPP1R13L

NM_006663

2.01

Exon13

Protein phosphatase 1, regulatory (inhibitor) subunit 13 like

 

STEAP3

NM_182915

2.22

Exon6

STEAP family member 3

TNFRSF14

NM_003820

2.39

Exon8

Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

Negative regulation of apoptosis

ERCC2

NM_001130867

0.42

Exon8

Excision repair cross-complementing rodent repair deficiency, complementation group 2

Anti-apoptosis

SERPINB2

NM_002575

0.48

Exon8

Serpin peptidase inhibitor, clade B (ovalbumin), member 2

Proliferation-associated

     

Cell growth

ACTA1

NM_001100

0.22

Exon6

Actin, alpha 1, skeletal muscle

NDRG4

NM_001130487

2.62

Exon5

NDRG family member 4

Cell cycle checkpoint

ERCC2

NM_001130867

0.42

Exon8

Excision repair cross-complementing rodent repair deficiency, complementation group 2

Multicellular organism growth

ERCC2

NM_001130867

0.42

Exon8

Excision repair cross-complementing rodent repair deficiency, complementation group 2

Cell proliferation

ERCC2

NM_001130867

0.42

Exon8

Excision repair cross-complementing rodent repair deficiency, complementation group 2

MT3

NM_005954

2.72

Exon3

Metallothionein 3

Cell cycle arrest

SART1

NM_005146

0.46

Exon11

Squamous cell carcinoma antigen recognized by T cells

Positive regulation of cell proliferation

IL11

NM_000641

7.99

Exon5

Interleukin 11

Negative regulation of cell proliferation

PTPRF

NM_002840

2.56

Exon34

Protein tyrosine phosphatase, receptor type, F

Migration-associated

     

Axon guidance

SLIT3

NM_003062

0.44

Exon1

Slit homolog 3 (Drosophila)

SEMA5A

NM_003966

2.90

Exon23

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

Motor axon guidance

EGR2

NM_000399

5.08

Exon2

Early growth response 2

Cell migration

PVR

NM_001135770

0.49

Exon3

Poliovirus receptor

Positive regulation of cell migration

LAMB1

NM_002291

0.46

Exon9

Laminin, beta 1

Regulation of cell shape

ARAP1

NM_001135190

0.45

Exon5

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Angiogenesis-associated

     

Positive regulation of angiogenesis

RUNX1

NM_001122607

0.40

Exon1

Runt-related transcription factor 1

Wound healing

SERPINB2

NM_002575

0.48

Exon8

Serpin peptidase inhibitor, clade B (ovalbumin), member 2

  1. Differentially spliced genes in human MSCs under hypoxia, were subjected to GO analysis as described in Methods.