Table 2 Serum clinical chemistry after administration of OTA (0, 70, 210 μg/kg body weight) for 2, 4 or 13 weeks
From: MicroRNA profiling of rats with ochratoxin A nephrotoxicity
Time (weeks) | Dose (μg/kg) | ALT (U/L) | AST (U/L) | ALB (g/L) | ALP(U/L) | GLU (mmol/L) | BUN (mmol/L) | CREA (umol/L) | HDL(mmol/L) | LDL(mmol/L) | LDH (U/L) |
|---|---|---|---|---|---|---|---|---|---|---|---|
2 | 0 | 45.17 ± 5.04 | 283 ± 63 | 52.4 ± 0.9 | 310 ± 31 | 3.37 ± 1.61 | 6.2 ± 0.5 | 37 ± 16 | 2.52 ± 0.31 | 0.59 ± 0.17 | 3484 ± 696 |
70 | 45.2 ± 6.30 | 241 ± 53 | 51.7 ± 2.9 | 315 ± 33 | 4.71 ± 1.07 | 6.2 ± 0.4 | 29 ± 2 | 2.91 ± 0.46 | 0.96 ± 0.42 | 3062 ± 632 | |
210 | 42.67 ± 6.44 | 208 ± 448 | 50.1 ± 2.1 | 305 ± 41 | 4.3 ± 1.03 | 6.2 ± 0.7 | 31 ± 10 | 2.37 ± 0.23 | 0.72 ± 0.18 | 2644 ± 506a | |
4 | 0 | 50.00 ± 3.08 | 240 ± 25 | 75.0 ± 3.5 | 288 ± 36 | 4.99 ± 1.1 | 5.7 ± 0.7 | 28 ± 3 | 2.96 ± 0.34 | 0.64 ± 0.2 | 3370 ± 338 |
70 | 52.83 ± 6.79 | 225 ± 61 | 76.5 ± 4.2 | 367 ± 78a | 5.76 ± 1.04 | 6.7 ± 0.8 | 32 ± 7 | 2.89 ± 0.47 | 0.82 ± 0.14 | 2965 ± 769 | |
210 | 52.33 ± 5.39 | 305 ± 61b | 72.4 ± 2.7 | 275 ± 14b | 3.71 ± 1.12b | 6.1 ± 0.9 | 34 ± 4 | 3.42 ± 0.18b | 0.83 ± 0.22 | 3842 ± 727b | |
13 | 0 | 56.50 ± 7.61 | 167 ± 17 | 49.2 ± 1.5 | 152 ± 17 | 7.91 ± 1.02 | 8.5 ± 0.5 | 43 ± 2 | 3.42 ± 0.55 | 0.77 ± 0.16 | 2043 ± 237 |
70 | 52.17 ± 2.99 | 152 ± 7 | 51.1 ± 2.4 | 153 ± 10 | 7.34 ± 0.63 | 8.7 ± 0.5 | 43 ± 4 | 2.93 ± 0.25 | 0.69 ± 0.09 | 1974 ± 153 | |
210 | 52.33 ± 4.23 | 140 ± 13a | 51.2 ± 2.4a | 157 ± 11 | 7.76 ± 0.99 | 8.5 ± 0.5 | 43 ± 9 | 2.69 ± 0.13a | 0.74 ± 0.15 | 1763 ± 208a |