Table 5 Deferentially expressed miRNAs in CH (A) or CM (B)

Up-regulated miRNAs

rno-miR-3065-3p

21.0

<0.0001

rno-miR-3556a

85.0

<0.0001

rno-miR-653

17.0

<0.0001

rno-miR-653

20.3

<0.0001

rno-miR-3596b

15.4

<0.0001

rno-miR-3596b

10.8

<0.0001

rno-miR-3556b

10.1

<0.0001

rno-miR-30c

4.8

<0.0001

rno-miR-504

8.4

<0.0001

rno-miR-145

4.2

<0.0001

rno-miR-3596a

8.3

<0.0001

rno-miR-19a

4.1

<0.0001

rno-miR-3596c

8.3

<0.0001

rno-miR-19b

4.1

<0.0001

rno-miR-30c

4.3

<0.0001

rno-miR-3590-5p

4.0

<0.0001

rno-miR-338

4.2

0.000126

rno-miR-3473

3.0

<0.0001

rno-miR-200c

3.7

0.006459

rno-miR-338

3.0

0.001122

Down-regulated miRNAs

rno-miR-133a

−28.6

<0.0001

rno-miR-218b

−98.6

<0.0001

rno-miR-133b

−28.6

<0.0001

rno-miR-130a

−63.9

<0.0001

rno-miR-128

−13.7

<0.0001

rno-miR-130b

−63.9

<0.0001

rno-miR-182

−13.3

<0.0001

rno-miR-3588

−31.3

<0.0001

rno-miR-190*

−10.6

<0.0001

rno-miR-129

−24.2

<0.0001

rno-miR-3587

−9.8

<0.0001

rno-miR-138

−11.5

<0.0001

rno-miR-135a

−9.2

<0.0001

rno-miR-182

−11.3

0.000154

rno-miR-135b

−9.2

<0.0001

rno-miR-133a

−6.7

<0.0001

rno-miR-186

−8.7

<0.0001

rno-miR-133b

−6.7

<0.0001

rno-miR-2964

−6.6

0.003196

rno-miR-136*

−5.7

0.022282

rno-miR-96

−6.6

0.003196

rno-miR-141

−5.6

<0.0001

rno-miR-378b

−5.7

<0.0001

rno-miR-3596c

−5.1

<0.0001

rno-miR-378

−5.7

<0.0001

rno-miR-3596d

−5.1

<0.0001

rno-miR-328b-3p

−4.4

0.009016

rno-miR-9b-5p

−4.8

0.005151

rno-miR-3596d

−4.2

<0.0001

rno-miR-216a

−3.5

0.007073

rno-miR-154*

−4.1

0.01503

rno-miR-466b-1-3p

−4.1

0.047095

rno-miR-151-3p

−3.8

0.000013

rno-miR-29a-5p

−3.7

0.024944

rno-miR-802-5p

−3.7

0.0001

rno-miR-1843-5p

−3.4

0.0001

rno-miR-138

−3.0

0.0001

rno-miR-802*

−3.0

0.000037