Figure 5
From: The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration
Intact distribution and central projections of peptidergic and non-peptidergic nociceptors in Dcc heterozygous mice. Panel A: Triple immunolabeling experiment showing similar distribution of CGRP-immunoreactivity, substance P-immunoreactivity, and binding of isolectin B4 (IB4) in dorsal root ganglion sections from Dcc wildtype and heterozygous littermates. Panel B: Triple immunolabeling experiment indicating that in the spinal cord dorsal horn the typical laminar organization of central terminals of peptidergic (CGRP- and substance P-expressing) and non-peptidergic (IB4-binding) nociceptors is intact in Dcc heterozygous mice, compared to wildtype littermates.