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Table 3 The integrated ranking of genes associated with the opioid adaptive traits

From: The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration

Gene

Score

Dcc

23.55

Sgpp2

22.51

Sgcz

21.51

Gm16724

21.06

Kank1

20.95

Rora

20.73

Myo5b

20.53

Tcf4

20.20

Dpp10

20.07

Ctif

20.01

Lhfpl3

20.00

Pik3c2g

19.95

Erbb4

19.92

L3mbtl4

19.68

Lrch1

19.59

  1. The genes most strongly associated with the five opioid adaptive phenotypes under study considered together are listed in the table. These traits include: mechanical OIH (Mech OIH), OIH measured using tail flick data (TF OIH), OIH measured using paw withdrawal testing (Therm OIH), morphine tolerance (Tolerance) and physical dependence (Dependence). Higher scores indicate stronger combined associations with the group of five traits.