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Table 5 Empirical type I error rates and powers for each method from 1000 replicates at significance level 0.05 when the sample sizes are 1000 for cases and controls and the genotype frequencies for controls are (0.1,0.36,0.54) with minor allele is the disease allele

From: A new association test based on disease allele selection for case–control genome-wide association studies

Λ 1 Λ 2

(1,1)

(1, 1.4) RM*

(1.1, 1.4)

(1.2, 1.4) AM*

(1.3, 1.4)

(1.4, 1.4) DM*

(1.5,1.4) ODM*

(0.9, 1.4) UDM*

ChiSQ

0.046

0.93

0.743

0.539

0.426

0.481

0.565

0.995

MAX3

0.04

0.944

0.771

0.601

0.473

0.486

0.507

0.995

GMS

0.04

0.929

0.756

0.609

0.471

0.49

0.517

0.992

CATT

0.043

0.936

0.807

0.659

0.459

0.314

0.194

0.974

MERT

0.044

0.88

0.763

0.656

0.517

0.409

0.302

0.933

GGM

0.043

0.952

0.786

0.635

0.484

0.46

0.437

0.995

New

0.049

0.926

0.755

0.616

0.485

0.514

0.556

0.988

  1. *RM: Recessive Model; AM: Additive Model; DM: Dominant Model; ODM: Over-dominant Model; UDM: Under-dominant Model.