Model | Estimate EA | Estimate AA | Estimate combined | p-value EA | p-value AA | p-value combined |
---|---|---|---|---|---|---|
Model 1: Covariates | ||||||
  Intercept | 26.91 | 30.21 | 27.63 | < 2×10−16 | < 2×10−16 | < 2×10−16 |
  PC1 | −50.11 | −6.91 | −98.82 | 0.788 | 0.939 | 2.40×10−29 |
  PC4 | 19.31 | −29.93 | 10.54 | 0.027 | 0.157 | 0.167 |
  PC8 | −3.18 | −28.41 | −30.20 | 0.934 | 0.008 | 0.002 |
  Sex | −1.26 | 2.49 | −0.46 | 1.76×10−5 | 3.67×10−5 | 0.081 |
  Age | 0.05 | −0.01 | 0.04 | 2.13×10−4 | 0.984 | 9.45×10−4 |
  AD | −0.15 | −0.37 | −0.20 | 0.062 | 0.018 | 0.004 |
  ND | −0.10 | 0.07 | −0.06 | 0.157 | 0.627 | 0.361 |
  PC1*Sex | 295.12 | −249.00 | −122.29 | 0.409 | 0.172 | 1.92×10−12 |
  Age*AD | −0.02 | −0.07 | −0.02 | 0.026 | 0.0006 | 3.20×10−4 |
Model 2: Covariates, GRSS & CNV | ||||||
  Intercept | 26.91 | 30.22 | 27.63 | < 2×10−16 | < 2×10−16 | < 2×10−16 |
  PC1 | −107.10 | −14.09 | −110.22 | 0.560 | 0.877 | 1.89×10−35 |
  PC4 | 20.20 | −30.04 | 10.14 | 0.019 | 0.153 | 0.176 |
  PC8 | 11.44 | −30.56 | −31.53 | 0.765 | 0.004 | 8.36×10−4 |
  Sex | −1.24 | 2.51 | −0.43 | 1.70×10−5 | 2.89×10−5 | 0.099 |
  Age | 0.05 | 0.01 | 0.04 | 2.03×10−4 | 0.963 | 8.15×10−4 |
  AD | −0.15 | −0.37 | −0.20 | 0.058 | 0.020 | 0.005 |
  ND | −0.12 | 0.09 | −0.07 | 0.087 | 0.566 | 0.253 |
  PC1*Sex | 170.80 | −261.80 | −131.38 | 0.627 | 0.150 | 3.91×10−14 |
  Age*AD | −0.01 | −0.06 | −0.02 | 0.032 | 0.001 | 6.59×10−4 |
  SNP-GRSS | 65.40 | 42.30 | 62.44 | 2.55×10−15 | 0.036 | 4.30×10−16 |
  Sex*SNP-GRSS | 39.96 | 70.47 | 44.37 | 0.014 | 0.076 | 0.003 |
  Del 16p12.3 | −0.60 | −0.61 | −0.57 | 0.079 | 0.511 | 0.075 |