Skip to main content

Table 4 Discriminative accuracy of covariates, SNP-GRSS and CNV predicting BMI category in European- and African-Americans

From: On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis

Model

AUC

95% CI

Asy. Sig. of Model

Δ AUC

% Δ AUC

pΔ AUC

Overweight: n = 1443 (61.4%)

   

1. Covariates

0.679

[0.657,0.700]

2.68×10−48

-

-

-

2. Model 1 + SNP-GRSS

0.692

[0.671,0.714]

9.23×10−56

0.013

1.91%

0.001

3. Model 2 + CNV

0.694

[0.672,0.715]

1.27×10−56

0.002

0.28%

0.372

Obese Class I: n = 632 (26.9%)

   

1. Covariates

0.621

[0.594,0.647]

2.74×10−19

-

-

-

2. Model 1 + SNP-GRSS

0.661

[0.637,0.686]

2.77×10−33

0.040

6.44%

0.0001

3. Model 2 + CNV

0.662

[0.638,0.687]

1.12x10−33

0.001

0.15%

0.662

Obese Class II: n = 264 (11.2%)

   

1. Covariates

0.648

[0.610,0.685]

5.22×10−15

-

-

-

2. Model 1 + SNP-GRSS

0.681

[0.646,0.716]

6.97×10−22

0.033

5.09%

0.025

3. Model 2 + CNV

0.690

[0.656,0.725]

5.58×10−24

0.009

1.32%

0.123

Obese Class III: n = 106, (4.5%)

   

1. Covariates

0.711

[0.660,0.762]

1.97×1013

-

-

-

2. Model 1 + SNP-GRSS

0.741

[0.692,0.790]

4.81×10−17

0.030

4.22%

0.029

3. Model 2 + CNV

0.750

[0.702,0.797]

3.15×10−18

0.009

1.21%

0.152

  1. Note: BMI = body mass index kg/m2, SNP = single nucleotide polymorphism, SNP-GRSS = genetic risk sum score constructed from imputed probability of carrying 32 BMI-associated SNPs weighted by effect size reported in Speliotes et al. 2010, CNV = copy number variation, AUC = area-under the receiver operator criteria curve, Asy. Sig. = asymptotic significance, Δ AUC = change in AUC from previous model, % Δ AUC = percent change in AUC from previous model, p Δ AUC = statistical significance of change in AUC, Overweight = BMI ≥ 25 kg/m2, Obese I = BMI ≥ 30 kg/m2, Obese II = BMI ≥ 35 kg/m2, Obese III = BMI ≥ 40 kg/m2, Covariates = PC1, PC4, PC8, sex, age, AD, ND, PC1*sex, age*AD, PC = principal component score, Age = age at interview, AD = alcohol dependence, ND = nicotine dependence.