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Table 5 Distribution of Hif KR494 unique genes in clinical Hif isolates

From: Comparative genomic analysis reveals distinct genotypic features of the emerging pathogen Haemophilus influenzae type f

Locus taga(HifGL)

Descriptionb

H. influenzae serotype f clinical isolates

  

KR494

G19

G20

K238

L11

L16

L21

L22

L24

L25

L29

L45

L50

L59

M1

M10

M14

M29

M54

S208

S229

No. of isolatec

Hib MinnA

NTHi 3655

000176

cw-hydrolase

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

-

+

+

+

+

+

19

+d

+d

000310

GST

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

000674a

RgDF1: sap 2

+

+

+

+

+

+

+

+

+

+

+

+

+

+

-

+

+

+

+

+

+

19

-

-

000799a

KNTase

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

000834a

RgDF 2: glp R

+

+

+

+

+

+

+

+

+

+

+

+

+

-

+

+

+

+

+

+

+

19

-

-

000837

TAA

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

000989a

RgDF 3: aef 3

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

001007a

RgDF 3:PI

+

+

+

+

+

+

+

+

+

+

+

+

+

+

-

+

+

+

-

+

+

18

-

-

001350a

RgDF 4: rnf

+

+

+

+

+

+

+

+

+

+

+

+

+

-

+

-

+

+

+

+

+

18

-

-

001363a

RgDF 4: PI

+

+

+

+

+

+

+

+

+

+

+

+

+

+e

-

+

+

+

+

+

+

19

-

-

001431

TAA

+

-

-

+

+

-

+

+

-

+

+

-

+

-

+

-

-

+

+

+

+

12

-

-

001444

Fe3+ transporter

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

001463

UHP

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

001635

RgDF 6: RHinfI

+

+

-

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

19

-

-

001636

RgDF 6: MHinfI

+

+

+

+

+

+

+

+

+

+

+

+

+

-

+

+

+

+

+

+

+

19

-

-

001664

HutZ

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

001672

Lpp

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

20

-

-

No. of CDS present

17

16

15

17

17

16

17

17

16

17

17

16

17

13

14

14

16

17

16

17

17

 

1

1

  1. aLocus tags were based on the Hif KR494 genome[15]. For PCRs targeting the contiguous loci, only the first locus is shown. Full information of the target genes, amplicon size and PCR conditions is described in Additional file 1.
  2. bAbbreviations: cw-hydrolase, cell wall-associated hydrolase; glp R, duplication of gene cluster involved in sugar and amino acid transport and metabolism; GST, glutathione S-transferase domain-containing protein; KNTase, kanamycin nucleotidyltranserase; Lpp,unknown lipoprotein; MHinfI,type f-specific adenine-specific methyltransferase HinfI; PI, prophage island; TAA, trimeric autotransporter; UHP, unknown function hypothetical protein; RHinfI,Type II restriction enzyme HinfI.
  3. cTotal number of Hif clinical isolates (excluding Hif KR494) with unique genes found in Hif KR494.
  4. dCDS was not found despite the presence of primer priming site in the NTHi 3655 genome (AAZF01000000) and Hib 10810 (NC_016809); PCR product had a smaller size.
  5. ePositive, but with a larger PCR product.
  6. +PCR positive (CDS present); -PCR negative (CDS absent).