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Table 6 Distribution of genes absent in Hif KR494 and other Hif clinical isolates

From: Comparative genomic analysis reveals distinct genotypic features of the emerging pathogen Haemophilus influenzae type f

Locusa

Description/geneb

Serotype f clinical isolates

  

KR494

G19

G20

K238

L11

L16

L21

L22

L24

L25

L29

L45

L50

L59

M1

M10

M14

M29

M54

S208

S229

No. of isolatec

Hib MinnA

NTHi 3655

Histidine biosynthesis

                        

  HI0468

his G

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

+

-

2

+

+

  HI0469

his D

-

+

+

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

-

3

+

+

  HI0470

his C

-

+

+

-

+

-

+

-

+

-

+

-

+

+

+

+

+

-

-

+

-

12

+

+

  HI0472

his H

-

-

+

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

-

2

+

+

Anaerobic fermentation of L-ascorbate

                   

  HI1024

ula D

-

-

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

-

-

1

-d

-d

Folate biosynthesis

                        

  HI1190

PTS

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

1

+

+

Zinc and secondary molybdenum transporter

                   

  HIB_07090

zit B

-

-

+

-

-

-

-

-

-

-

-

-

-

+

+

-

-

-

-

+

+

5

+

+

  HI1470

mol C

-

-

+

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

-

2

+

-d

  HI1472

mol A

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

0

+

-d

hmg locus involved in LOS glycoform

                     

  HI0871

sia A

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

0

+

+

  HI0872

wba P

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

 

-

-

-

0

+

+

No. of CDSs present

0

2

5

0

1

0

1

0

1

0

1

0

1

3

5

3

1

0

0

3

1

 

10

8

  1. aLocus tags were based upon the genome of Rd Kw20 except HIB_07090 is based on Hib 10810. For PCR targeting the contiguous loci, only the first locus is shown. Full information of the target genes, amplicon size and PCR conditions is described in Additional file 1.
  2. bAbbreviations: PTS, 6-pyruvoyl tetrahydrobiopterin synthase in folate biosynthesis.
  3. cTotal number of Hif clinical isolates (excluding KR494) with genes that were absent in Hif KR494.
  4. dCDSs that were present in Rd Kw20 but not in NTHi 3655 or Hib MinnA.
  5. +PCR positive (CDS present); -PCR negative (CDS absent).