The role of ribonucleases in regulating global mRNA levels in the model organism Thermus thermophilus HB8

BMC Genomics

Table 1 Putative RNases of Thermus thermophilus HB8

Protein name	ORF ID	Accession number	Major substrate	Activity	Reference	B. subtilis	E. coli
RNase J	TTHA1140	YP_144406.1	mRNA	Endo & Exo	[5, 15]	○ (40%)	×
RNase Y	TTHA1817	YP_145083.1	mRNA	Endo	[16]	○ (49%)	×
RNase II	TTHA1534	YP_144800.1	mRNA	Exo	[17]	×	○
RNase R	TTHA0910	YP_144176.1	mRNA	Exo	[17]	○ (31%)	○ (26%)
PNPase	TTHA1139	YP_144405.1	mRNA	Exo	[17]	○ (49%)	○ (46%)
RNase HI	TTHA1556	YP_144822.1	DNA/RNA hybrid	Endo	[18]	×	○ (50%)
RNase HII	TTHA0198	YP_143464.1	DNA/RNA hybrid	Endo	[18]	○ (38%)	○ (40%)
RNase P*	TTHA0445	YP_143711.1	tRNA precursor	Endo	[19]	○ (22%)	○ (18%)
Argonaute	TTHB068	YP_145307.1	Phage RNA	Endo	[20]	×	×
RecJ-like protein	TTHA0118	YP_143384.1	Short RNA	Exo	[21]	○ (21%)	×
β-CASP family protein	TTHA0252	YP_143518.1	mRNA?	Exo	[6]	×	×
YbeY	TTHA1045	YP_144311.1	rRNA precursor?	Endo	[16]	○ (29%)	○ (21%)
PhoH-like protein	TTHA1046	YP_144312.1	?	??	[22]**	○ (50%)	○ (47%)
L-PSP	TTHA0137	YP_143403.1	?	Endo	[23]	○ (50%)	○ (37%)
PIN-domain protein	TTHA0540	YP_143806.1	?	??	[24, 25]	○ (29%)	×

The circles and crosses indicate the presence and absence of an ortholog, respectively.
The numbers in parentheses are the percentage amino acid sequence identity of that protein with its homologs.
*The catalytic unit of RNase P is RNA.
**Predicted by sequence similarity without experimental evidence.

ISSN: 1471-2164