Figure 4

The association of SNVs in different gene regions and differential expression or splicing. Association of SNVs in different gene regions and differential expression or splicing, as reported in Gillett et al. [38]. The fractions of genes that have SNVs in i) coding region, ii) UTR or iii) splice sites were measured. a, Genes predicted to be differentially expressed between DA/K and PVG compared to genes with no differential expression in this condition. Three different levels of fold change were used to categorize differentially expressed genes, resulting in 88 genes with fold change (FC) > 2, 214 genes with FC > 1.7, 520 genes with FC > 1.5 and 14140 genes with no differential expression. b, Alternatively spliced genes compared with genes with no evidence of alternative splicing in this condition. Three significance levels were used to categorize significant alternative splicing in genes, resulting in 123 genes in the highest significance category p < 0.00001, 278 (p < 0.01), 613 (p < 0.1) and 13208 genes that were not considered alternatively spliced.