From: Transcriptome profiling of granulosa cells from bovine ovarian follicles during atresia
Biological process | Molecular function | Cellular component | Symbol | Entrez gene name |
---|---|---|---|---|
Regulation of vascularity Angiogenesis (P = 0.009) |  |  | CYR61 | cysteine-rich angiogenic inducer |
COL18A1 | collagen 18 | |||
THBS1 | thrombospondin 1 | |||
CXCR4 | chemokine receptor 4 | |||
ANGPT2 | angiopoietin 2 | |||
VEGFA | vascular endothelial growth factor A | |||
Energy metabolism Glycogen biosynthetic process (P = 0.044) | Insulin-like growth factor binding, two component sensor activity | microsome | ISR2 | insulin receptor 2 |
EGFR | epidermal growth factor receptor | |||
HSP90AA1 | heat shock protein 90Â kDa alpha (cytosolic), class A member 1 | |||
PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | |||
IGFBP2 | insulin-like growth factor binding protein 2 | |||
CTGF | connective tissue growth factor | |||
CYR61 | cysteine-rich angiogenic inducer | |||
MGST1 | glutathione transferase 1 | |||
CALR | calreticulin | |||
PTGES | prostaglandin E synthase | |||
PLC4 | phospholipase C, beta 4 | |||
OPTN | optineurin | |||
ASPSCR1 | alveolar soft part sarcoma chromosome region, candidate 1 | |||
Cell Cycle Mitosis (P = 2.3 × 10-5) |  | Condensed chromosome kinetochore, spindle | CCNA2 | cyclin A2 |
CCNB1 | cyclin B1 | |||
CCNB2 | cyclin B2 | |||
UBE2 | ubiquitin conjugating enzyme 2 | |||
CDK1 | cyclin-dependent kinase 1 | |||
NUSAP | nucleolar and spindle associated protein 1 | |||
SKA1 | spindle and kinetochore associated complex subunit 1 | |||
NUP85 | nucleoporin 85Â kDa | |||
CENPN | centromere protein N | |||
CENPO | centromere protein O | |||
ZW10 | kinetochore associated homolog | |||
BUB1 | budding inhibited by benzimidazoles 1 homolog (yeast) | |||
STK | serine/threonine kinase | |||
Extracellular matrix Extracellular matrix organisation (P = 0.01) | Heparin binding, extracellular matrix binding | Basement membrane | COL1A1 | collagen type I, alpha 1 |
COL1A2 | collagen type I, alpha 2 | |||
COL3A1 | collagen type III, alpha 1 | |||
COL4A3 | collagen type IV, alpha 3 | |||
COL4A4 | collagen type IV, alpha 4 | |||
COL18 | collagen type XVIII | |||
LAMB1 | laminin, beta 1 | |||
VCAN | versican | |||
FMOD | fibromodulin | |||
ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | |||
ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | |||
MMP2 | matrix metallopeptidase 2 | |||
TIMP1 | TIMP metallopeptidase inhibitor 1 | |||
OGN | osteoinductive factor/osteoglycin | |||
OSF-2 | osteoblast-specific factor 2 | |||
SPARCL1 | SPARC-like 1 (hevin) | |||
ASPN | asporin | |||
Inflammation | Â | Fibrinogen complex | THBS1 | thrombospondin 1 |
NOS biosynthesis (P = 0.044) | CALR | calreticulin | ||
Antigen processing (P = 0.026) | BOLA-A | major histocompatibility complex (MHC), class I, A | ||
TGFβ receptor signalling pathway (P = 0.05) | BOLA-N | MHC class I antigen | ||
Fibrinolysis (P = 0.09) | ||||
Cell migration | Â | Â | CXCR4 | chemokine receptor 4 |
Axon guidance (P = 0.0008) | ABLIM1 | actin binding LIM protein 1 | ||
COL18 | collagen type XVIII | |||
EFNA5 | ephrin A5 | |||
THBS1 | thrombospondin 1 | |||
EGFR | epidermal growth factor receptor | |||
TDGF | teratocarcinoma-derived growth factor 1 | |||
F2RL1 | coagulation factor II (thrombin) receptor-like 1 | |||
INSR | insulin receptor | |||
MAPK activity (P = 0.002) |  |  | THBS1 | thrombospondin 1 |
TDGF | teratocarcinoma-derived growth factor 1 | |||
 |  |  | INSR | insulin receptor |