Chromosome | Diseaseb | WTCCC | SRR ≥ 2c | ± 50 Kbc |
|---|
5p13
| CD | 0 | - | - |
10q24
| CD | 1 | - | - |
10q25
| T2D | 1 | - | - |
9p21
| CAD | 2 | - | - |
10q21
| CD | 3 | - | - |
16q12
| CD | 4 | - | - |
16q12
| T2D | 1 | - | + 1 |
5q33
| CD | 2 | - | + 1 |
1p13
a
| RA | 7 | - | + 1 |
1p13
a
| T1D | 7 | - | + 1 |
16p13
| T1D | 8 | - | + 1 |
16p12
| BD | 9 | - | + 1 |
1p31
| CD | 1 | - | + 2 |
2q37
| CD | 1 | - | + 2 |
18p11
| CD | 1 | - | + 2 |
12q24
| T1D | 15 | - | + 2 |
12q13
| T1D | 26 | - | + 3 |
3p21
| CD | 18 | + 7 | + 9 |
| | Total | 107 | + 7 | + 26 |
- aThese two loci overlap.
- bCD = Crohn’s disease, T2D = Type 2 diabetes, CAD = Coronary artery disease, RA = Rheumatoid arthrtitis, T1D = Type 1 diabetes, BD = Bipolar disorder.
- cSRR ≥ 2 for the gene definition extended to reach a cumulative SRR ≥ 2 in each direction; and ± 50 Kb for gene definition extended to this length in each direction. Only changes in the number of genes, not in their identity, were observed between the three lists:- no differences with the genes highlighted by the WTCCC authors; + number of additional genes beyond the highlighted by the WTCCC authors. A full list of genes in each loci is available as Additional file 1: Table S1.
