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Figure 2 | BMC Genomics

Figure 2

From: Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming

Figure 2

Growth data for selected treatment cohorts and controls from postnatal days 1 to 30. Leptin treatment (d3-13) is indicated by a shaded background. Weaning at day 22 is indicated with a vertical line. Plotted values indicate the average weight for each cohort as a percentage of control values: surrounding shaded areas show +/− s.e.m. at each age. A, D: Values for AD/Lep/Chow (blue) relative to AD/Sal/Chow (black) for females (A) and males (D) demonstrate a significant growth restriction in both sexes during leptin treatment. B, E: Values for UN/Lep/Chow (blue) relative to UN/Sal/Chow (black) for females (B) and males (E) demonstrate that in offspring of undernourished mothers there is an even more profound growth restriction during leptin treatment. Importantly, in females, but not in males, there is a pronounced fallback in body mass relative to control during and immediately following weaning (see text for discussion). C, F: Values for UN/Sal/Chow and UN/Lep/Chow relative to AD/Sal/Chow for females (C) and males (F). The postweaning fallback in UN/Lep/Chow females is also seen when measured relative to AD/Sal/Chow, therefore it is not simply a consequence of catch-up growth in UN/Sal/Chow.

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