Table 3 Genes which show a significant interaction between maternal nutritional status and postnatal leptin treatment effects, an expression change of at least 1.25 fold in the UN/Sal/HF cohort (with metabolic syndrome), and where this cohort is an outlier from the other experimental groups

Ifit1

2.95

3.52

AB

56824

Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 1 (Ifit1), mRNA.

Ppp1r3b

1.46

2.40

AB, C

192280

Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 3B (Ppp1r3b), mRNA.

Ca3

1.29

2.38

AB, C

54232

Rattus norvegicus carbonic anhydrase 3 (Ca3), mRNA.

Stac3

1.27

2.35

AB, C

362895

PREDICTED: Rattus norvegicus SH3 and cysteine rich domain 3 (predicted) (Stac3_predicted), mRNA.

TUBB2A

1.79

2.33

AB, BC

498736

PREDICTED: Rattus norvegicus similar to tubulin, beta 2 (TUBB2A), mRNA.

LEAP2

1.52

2.29

AB, C

497901

PREDICTED: Rattus norvegicus similar to Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) (LEAP2), mRNA.

Slc34a2

1.45

1.88

AB, C

84395

Rattus norvegicus solute carrier family 34 (sodium phosphate), member 2 (Slc34a2), mRNA.

Pgd

1.24

1.77

AB

362660

PREDICTED: Rattus norvegicus phosphogluconate dehydrogenase (Pgd), mRNA.

Afp

1.33

1.76

AB, C

24177

Rattus norvegicus alpha-fetoprotein (Afp), mRNA.

VNN3

1.17

1.70

AB, C

498992

PREDICTED: Rattus norvegicus similar to Vanin-3 (predicted) (VNN3_predicted), mRNA.

Avpr1a

1.42

1.70

AB, C

25107

Rattus norvegicus arginine vasopressin receptor 1A (Avpr1a), mRNA.

Laptm4b

0.94

1.68

AB

315047

Rattus norvegicus lysosomal-associated protein transmembrane 4B (Laptm4b), mRNA.

Igf2bp3

1.23

1.67

AB, C

312320

PREDICTED: Rattus norvegicus insulin-like growth factor 2, binding protein 3 (Igf2bp3), mRNA.

Aldh1b1

1.08

1.64

AB, C

298079

Rattus norvegicus aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA.

Amy1a

1.33

1.64

AB, C

24203

Rattus norvegicus amylase, alpha 1A (salivary) (Amy1a), mRNA.

Aadac

1.19

1.62

AB, C

57300

Rattus norvegicus arylacetamide deacetylase (esterase) (Aadac), mRNA.

Pipox

1.56

1.60

AB, BC

303272

Rattus norvegicus pipecolic acid oxidase (Pipox), mRNA.

Sez6

1.28

1.58

AB, C

192247

PREDICTED: Rattus norvegicus seizure related 6 homolog (mouse) (Sez6), mRNA.

Olr59

1.31

1.56

AB, C

170816

Rattus norvegicus olfactory receptor 59 (Olr59), mRNA.

RGD1563713

1.31

1.56

AB

316550

PREDICTED: Rattus norvegicus similar to Rab18 (RGD1563713), mRNA.

Gpd2

1.28

1.56

AB, C

25062

Rattus norvegicus glycerol-3-phosphate dehydrogenase 2, mitochondrial (Gpd2), nuclear gene encoding mitochondrial protein, mRNA.

Bche

1.20

1.51

AB, C

65036

Rattus norvegicus butyrylcholinesterase (Bche), mRNA.

Otc

1.32

1.51

AB, C

25611

Rattus norvegicus ornithine carbamoyltransferase (Otc), nuclear gene encoding mitochondrial protein, mRNA.

Dnmt3b

0.95

1.51

AB, AC, BC

444985

Rattus norvegicus DNA methyltransferase 3B (Dnmt3b), mRNA.

Clpx

1.35

1.50

AB, BC

300786

Rattus norvegicus ClpX caseinolytic peptidase X homolog (E. coli) (Clpx), mRNA.

Slc7a7

1.03

1.49

AB, C

83509

Rattus norvegicus solute carrier family 7 (cationic amino acid transporter, y + system), member 7 (Slc7a7), mRNA.

Dpys

1.04

1.49

AB, C

65135

Rattus norvegicus dihydropyrimidinase (Dpys), mRNA.

Fam82a

1.34

1.48

AB, C

313840

Rattus norvegicus family with sequence similarity 82, member A (Fam82a), mRNA.

Slc16a1

1.15

1.41

AB

25027

Rattus norvegicus solute carrier family 16 (monocarboxylic acid transporters), member 1 (Slc16a1), mRNA.

Adhfe1

1.32

1.40

AB, C

362474

Rattus norvegicus alcohol dehydrogenase, iron containing, 1 (Adhfe1), mRNA.

Inhba

1.10

1.40

AB, BC

29200

Rattus norvegicus inhibin beta-A (Inhba), mRNA.

TMEM70

1.13

1.38

AB, C

500384

PREDICTED: Rattus norvegicus similar to RIKEN cDNA 2210416 J16 (predicted) (TMEM70_predicted), mRNA.

RGD1560797

1.08

1.38

A, BC

306115

PREDICTED: Rattus norvegicus similar to glyceraldehyde-3-phosphate dehydrogenase (predicted) (RGD1560797_predicted), mRNA.

RGD1310209

1.08

1.35

AB, C

362019

PREDICTED: Rattus norvegicus similar to KIAA1324 protein (predicted) (RGD1310209_predicted), mRNA.

Maob

1.24

1.34

AB

25750

Rattus norvegicus monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA.

Lrp5

1.09

1.34

AB

293649

PREDICTED: Rattus norvegicus low density lipoprotein receptor-related protein 5 (predicted) (Lrp5_predicted), mRNA.

Klrg1

1.10

1.34

AB, C

58975

Rattus norvegicus killer cell lectin-like receptor subfamily G, member 1 (Klrg1), mRNA.

Atf4

1.24

1.33

AB

79255

Rattus norvegicus activating transcription factor 4 (tax-responsive enhancer element B67) (Atf4), mRNA.

Phf11

1.15

1.33

AB, C

361051

PREDICTED: Rattus norvegicus PHD finger protein 11 (predicted) (Phf11_predicted), mRNA.

Rora

1.25

1.33

AB

300807

PREDICTED: Rattus norvegicus RAR-related orphan receptor alpha (predicted) (Rora_predicted), mRNA.

Serpina3m

1.17

1.32

AB, C

299276

PREDICTED: Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3 M (Serpina3m), mRNA.

PLBD1

1.15

1.31

AB, C

297694

Rattus norvegicus similar to RIKEN cDNA 1100001H23 (PLBD1), mRNA.

ANGPTL3

1.17

1.31

AB, C

502970

PREDICTED: Rattus norvegicus similar to angiopoietin-related protein 3 (ANGPTL3), mRNA.

Agtr1a

1.02

1.30

AB

24180

Rattus norvegicus angiotensin II receptor, type 1 (AT1A) (Agtr1a), mRNA.

Apon

1.09

1.30

AB, C

304603

Rattus norvegicus apolipoprotein N (Apon), mRNA.

Lgals5

1.21

1.29

AB

25475

Rattus norvegicus lectin, galactose binding, soluble 5 (Lgals5), mRNA.

Cabc1

1.23

1.28

AB

360887

Rattus norvegicus chaperone, ABC1 activity of bc1 complex homolog (S. pombe) (Cabc1), nuclear gene encoding mitochondrial protein, mRNA.

Sdcbp

1.12

1.27

AB

83841

Rattus norvegicus syndecan binding protein (Sdcbp), mRNA.

CP

1.07

1.27

AB

294942

PREDICTED: Rattus norvegicus hypothetical CP (CP), mRNA.

Irf6

1.14

1.26

AB

364081

PREDICTED: Rattus norvegicus interferon regulatory factor 6 (predicted) (Irf6_predicted), mRNA.

Hsd17b13

1.07

1.26

AB, C

305150

PREDICTED: Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), mRNA.

Mst1

1.17

1.26

AB

24566

Rattus norvegicus Macrophage stimulating 1 (hepatocyte growth factor-like) (Mst1), mRNA.

Btg1

1.13

1.25

AB, C

29618

Rattus norvegicus B-cell translocation gene 1, anti-proliferative (Btg1), mRNA.

MUT

1.19

1.25

AB

497857

PREDICTED: Rattus norvegicus similar to MYLE protein (Dexamethasone-induced protein) (predicted) (MUT_predicted), mRNA.

Pxmp4

−1.38

−3.51

AB

282634

Rattus norvegicus peroxisomal membrane protein 4 (Pxmp4), mRNA.

Igfbp2

−2.11

−3.09

AB, C

25662

Rattus norvegicus insulin-like growth factor binding protein 2 (Igfbp2), mRNA.

Sds

−1.54

−2.49

AB

25044

Rattus norvegicus serine dehydratase (Sds), mRNA.

Tnfsf13

−2.22

−2.42

AB

287437

Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 13 (Tnfsf13), mRNA.

Hnrpab

−1.19

−2.09

AB, C

83498

Rattus norvegicus heterogeneous nuclear ribonucleoprotein A/B (Hnrpab), mRNA.

Asl

−1.33

−2.07

AB, C

59085

Rattus norvegicus argininosuccinate lyase (Asl), mRNA.

Cd63

−1.36

−1.94

AB, C

29186

Rattus norvegicus CD63 antigen (Cd63), mRNA.

RGD1560687

−1.25

−1.85

AB, C

500804

PREDICTED: Rattus norvegicus similar to Ferritin light chain (Ferritin L subunit) (predicted) (RGD1560687_predicted), mRNA.

Trpm6

−1.27

−1.76

AB, C

293874

PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily M, member 6 (predicted) (Trpm6_predicted), mRNA.

Hspb1

−1.34

−1.68

AB, C

24471

Rattus norvegicus heat shock 27 kDa protein 1 (Hspb1), mRNA.

Ftl1

−1.11

−1.60

AB, C

29292

Rattus norvegicus ferritin light chain 1 (Ftl1), mRNA.

Mgst2

−1.43

−1.54

AB, BC

295037

PREDICTED: Rattus norvegicus microsomal glutathione S-transferase 2 (predicted) (Mgst2_predicted), mRNA.

Znf593

−1.19

−1.53

AB, C

298546

PREDICTED: Rattus norvegicus zinc finger protein 593 (predicted) (Znf593_predicted), mRNA.

Ppcs

−1.43

−1.52

AB, C

298490

Rattus norvegicus phosphopantothenoylcysteine synthetase (Ppcs), mRNA.

Mthfd1

−1.38

−1.47

A, BC

64300

Rattus norvegicus methylenetetrahydrofolate dehydrogenase (NADP + dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (Mthfd1), mRNA.

Pmm1

−1.26

−1.47

A, B, C

300089

Rattus norvegicus phosphomannomutase 1 (Pmm1), mRNA.

Aqp11

−1.35

−1.45

AB

286758

Rattus norvegicus aquaporin 11 (Aqp11), mRNA.

Csrp2

−1.34

−1.45

A, B, C

29317

Rattus norvegicus cysteine and glycine-rich protein 2 (Csrp2), mRNA.

Pla2g12a

−1.27

−1.44

AB, BC

362039

PREDICTED: Rattus norvegicus phospholipase A2, group XIIA (predicted) (Pla2g12a_predicted), mRNA.

Tifa

−1.24

−1.42

AB, C

310877

Rattus norvegicus TRAF-interacting protein with forkhead-associated domain (Tifa), mRNA.

Hexb

−1.17

−1.41

AB, C

294673

Rattus norvegicus hexosaminidase B (Hexb), mRNA.

Rps14

−1.15

−1.41

AB, C

29284

Rattus norvegicus ribosomal protein S14 (Rps14), mRNA.

Ier3

−1.38

−1.40

AB

294235

Rattus norvegicus immediate early response 3 (Ier3), mRNA.

Paics

−1.40

−1.40

AB

140946

Rattus norvegicus phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (Paics), mRNA.

Txnl5

−1.32

−1.38

AB

287474

PREDICTED: Rattus norvegicus thioredoxin-like 5 (predicted) (Txnl5_predicted), mRNA.

Pla1a

−1.35

−1.38

AB

85311

Rattus norvegicus phospholipase A1 member A (Pla1a), mRNA.

Cyp8b1

−1.08

−1.37

AB, C

81924

Rattus norvegicus cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1), mRNA.

Creb3

−1.28

−1.36

AB, C

298400

Rattus norvegicus cAMP responsive element binding protein 3 (Creb3), mRNA.

Cd320

−1.06

−1.36

AB, C

362851

PREDICTED: Rattus norvegicus CD320 antigen (Cd320), mRNA.

Nola2

−1.10

−1.34

AB, C

287273

PREDICTED: Rattus norvegicus nucleolar protein family A, member 2 (predicted) (Nola2_predicted), mRNA.

Sult1c1

−0.87

−1.32

AB

65185

Rattus norvegicus sulfotransferase family, cytosolic, 1C, member 1 (Sult1c1), mRNA.

Slc11a2

−1.16

−1.32

AB, BC

25715

Rattus norvegicus solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2), mRNA.

Btbd9

−1.19

−1.31

A, BC

294318

Rattus norvegicus BTB (POZ) domain containing 9 (Btbd9), mRNA.

Htatip2

−1.20

−1.30

AB, C

292935

PREDICTED: Rattus norvegicus HIV-1 tat interactive protein 2, homolog (human) (predicted) (Htatip2_predicted), mRNA.

Ctsl1

−1.09

−1.29

AB, C

25697

Rattus norvegicus cathepsin L1 (Ctsl1), mRNA.

Psmb3

−1.14

−1.29

AB, C

29676

Rattus norvegicus proteasome (prosome, macropain) subunit, beta type 3 (Psmb3), mRNA.

Sat2

−1.16

−1.29

AB

360547

PREDICTED: Rattus norvegicus spermidine/spermine N1-acetyl transferase 2 (predicted) (Sat2_predicted), mRNA.

Gtf2b

−1.15

−1.29

AB, C

81673

Rattus norvegicus general transcription factor IIB (Gtf2b), mRNA.

Eppb9

−1.10

−1.26

AB, BC

287383

PREDICTED: Rattus norvegicus endothelial precursor protein B9 (predicted) (Eppb9_predicted), mRNA.

Sdf2

−1.05

−1.26

AB

287470

PREDICTED: Rattus norvegicus stromal cell derived factor 2 (predicted) (Sdf2_predicted), mRNA.

Wdr45

−1.17

−1.26

AB, C

302559

Rattus norvegicus WD repeat domain 45 (Wdr45), mRNA.

Psma5

−1.20

−1.26

AB, C

29672

Rattus norvegicus proteasome (prosome, macropain) subunit, alpha type 5 (Psma5), mRNA.