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Table 4 The transcription profiles of alternative carbon utilization and phenotype-related genes among TRKOs

From: The Rbf1, Hfl1 and Dbp4 of Candida albicans regulate common as well as transcription factor-specific mitochondrial and other cell activities

Biological processes

rbf1Δ

hfl1Δ

dpb4Δ

Lipid metabolism

(n = 62) a

(n = 52)

(n = 19)

Dw-Peroxins (4/4)b

Dw-Peroxins (5/5)

 

Dw-lipid catabolism(29/31)

Dw-lipid catabolism(14/17)

Up-lipid catabolism (6/9)

  & glyoxylate cycle (2/2)

  & glyoxylate cycle(2/2)

  & glyoxylate cycle(2/2)

Dw-PL biosynthesis (10/12)

Dw-PL biosynthesis (15/17)

Dw-PL biosynthesis (4/4)

Up-PL catabolism (3/4)

Up-PL catabolism (2/2)

Up-PL catabolism (3/3)

Dw-SL biosynthesis (3/4)

Dw-SL biosynthesis (2/2)

 

Dw-ERG biosynthesis (2/4)

Dw-ERG biosynthesis (3/4)

Up-ERG biosynthesis (2/2)

Non-glucose and glucose utilization

(n = 31)

(n = 32)

(n = 12)

Dw-carbon utilization (26)

Dw-carbon utilization (23)

Up-carbon utilization (9)

  GAL1, GAL10

  GAL1, 10,102,7

 

Up-fermentation

Up-fermentation

Up-fermentation

  glycolysis

  glycolysis

  glycolysis

  glycogen

  glycogen

  glycogen

  glucose utilization

  glucose utilization

  glucose utilization

  xylose

  trehalose

  xylose

Amino acid metabolism

(n = 31)

(n = 28)

(n = 19)

Dw-aa biosynthesis (8)

Dw-aa biosynthesis (9)

Dw-aa biosynthesis (8)

Up-aa biosynthesis(3)

  MET2,3,10,15

MET2,3,6,10,13,14

Dw-aa catabolism (5)

Dw-aa catabolism (5)

Dw-aa catabolism (5)

 

  ARO3, ARO8

 

Up-aa catabolism(9)

Up-aa catabolism(8)

Up-aa catabolism (6)

ARO9,ARO10

  ARO9,ARO10

 

Up-sulfur/nitrogen assimilation (6)

Dw-sulfur/nitrogen assimilation (6)

 

Morphogenesis

(n = 27)

(n = 33)

(n = 17)

Up-hyphal formation (13)

Up-hyphal formation (12)

Up-hyphal formation (8)

ECE,1 HWP1,DEF1, HGC1,FGR43

ECE1, HWP1, FGR18 , HGC1

FGR6-1,3,4,10, RBR1, IHD2

RBR1, IHD2,FGR6-1,4,10

FGR43, RBR1,IHD2

Transporters

(n = 101)

(n = 80)

(n = 37)

Dw: sugar, amino acid, MSF

Dw: sugar, amino acid,MSF

Dw: lactate, polyamine

  sterol/PL, nucleosides,

  sterol/PL, nicotinamide,

 

  choline, nicotinamide,

  CDRs efflux pump, urea

 

  ion (K+, NH4+, Ca+2, P-, Cl-)

  ion (S-, NH4+, Zn+2, P-)

 

Up: urea, allantoate

Up: spermidine/polyamine

Up: glucose, acetate, MSF

  spermidine/polyamine

  cation (H+, Ca+2,Cu+2, Fe+3)

  fatty acid, aa,

  cation (H+, Cu+2, Fe+3)

  ions (H+, Cu+2, Fe+3 , S-)

  1. a: Total number of genes in this group;
  2. b: x/y indicates “x” number of genes are down (Dw) or up (Up) regulated among total of “Y” number of genes in this metabolic process.