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Figure 4 | BMC Genomics

Figure 4

From: 5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation

Figure 4

Lineage specific activation of distal TFBSs in cluster 2. (A) The enriched H3K4me1/2 in NPCs or endomesoderm cells suggests the potential lineage specific enhancer activation of the TFBSs in cluster 2 after differentiation. (B) The target genes of cluster 2 in NPCs identified using ChIA-PET become significantly upregulated (p-value:0.04) when they gained interactions. The expression change in MEF is compared as a control (p-value:0.12).

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BMC Genomics

ISSN: 1471-2164

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