Figure 2

Rainbow trout targets were identified and their functional enrichment for specific GO terms analyzed as described in the text. A particular enrichment was noted for pathways involved in cell cycle regulation, cell proliferation and differentiation. Compared to the comprehensive identification and validation of murine targets provided by Tsai et al. [30], 11% of rainbow trout targets were predicted to be conserved targets. All of the conserved targets (dditl4, igf2, parp3, rtn3, serpinh1, socs6, ucp2a, slc2a1 and adam10) are enriched in pathways regulating cell cycle, cell proliferation and differentiation, indicating an evolutionary conservation of specific miRNA-122 target relationships that govern these processes.