Figure 9

Recovery of metabolic pathway components. The networks shown above depict A. the Krebs cycle, and B. the folate pathway as represented by iPath. The nodes represent metabolites, and the edges represent metabolic transformations. Green edges indicate pathways that were found in both N. vectensis and E. lineata. Red pathways were only found in N. vectensis, and yellow pathways were only found in E. lineata. Gray and black edges indicate pathways that were not found in either anemone, in the case of gray edges because no Enzyme Commission numbers map to these edges, and thus they were impossible to detect in our analysis. List of gene name abbreviations for panels A and C are as follow: gltA = citrate synthase; mdh = malate dehydrogenase; aceB = malate synthase A; DAO = D-amino-acid oxidase; aceA = isocitrate lyase; gdhA = glutamate dehydrogenase; sucA = 2-oxoglutarate decarboxylase; LSC1 = succinate-CoA ligase; mcmA1 = methylmalonyl-CoA mutase N-terminal domain; SDHA = succinate dehydrogenase complex, subunit A; gabD = succinate-semialdehyde dehydrogenase I; UQCRB = ubiquinol-cytochrome c reductase binding protein; folP = dihydropteroate synthase; glyA = serine hydroxymethyltransferase; purN = phosphoribosylglycinamide formyltransferase; metF = 5,10-methylenetetrahydrofolate reductase; MTHFS = 5,10-methenyltetrahydrofolate synthetase; ftcD = glutamate formiminotransferase; folA = dihydrofolate reductase; folD = bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase; ppc = phosphoenolpyruvate carboxylase; acnA = aconitate hydratase 1; icd - isocitrate dehydrogenase; ldh = L-lactate dehydrogenase; fumA = fumarate hydratase; COX = Cytochrome c oxidase; atpA = ATP synthase subunit alpha; gabT = 4-aminobutyrate aminotransferase; NDU = NADH dehydrogenase. C. A selection of species that share ancestry with E. lineata at various evolutionary distance. The bar graph and numbers represent the amount of shared EC numbers between that species and Edwardsiella lineata. The species are E. coli, S. cereviseae, H. sapiens, D. melanogaster, C. elegans, H. magnipapillata, N. vectensis, and E. lineata.