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Figure 2 | BMC Genomics

Figure 2

From: SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy

Figure 2

Mouse cell lines have contamination and widespread aneuploidy. Neighbor-joining tree of 117 cell line samples based on genotypes from 3,552 SNP markers. Node colors show the support for each clade, based on 100 resamplings (light blue = lower support, dark blue = higher support). Samples labeled in red are from the Ba/F3 cell line, which was reported to be of BALB origin but is actually derived from C3H. Asterisks denote (*) cell lines known to be derived from cancer tissue, and (**) cell lines of unknown origin. The four circular tracks (from inside to outside) show alignment score (blue), presence of a secondary genetic background (orange), cross-contamination level (purple) and number of chromosomes with evidence of copy number change (red = loss, green = gain). Labels identify groups of cell lines derived from classical inbred strains (129, A, BALB, C3H, C57BL, DBA), intercross (C57BL Hybr = hybrid between C57BL and another background, CCF1 = intercross between two Collaborative Cross (CC) founder strains), Swiss mice (including commercial outbred stocks), wild-derived strains of M. m. musculus or M. m. castaneus origin (M. m. mus, cas), wild mice on non-M. musculus origin (other species), and other backgrounds (Ma/MyJ and PL/J are classical inbred strains, IL6211 is a CC line, and JR4 is derived from a 129xCAST hybrid).

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