Table 3 Top 20 genes with largest difference in expression and differential methylation between fetal and adult livers
From: Genetic and epigenetic regulation of gene expression in fetal and adult human livers
Gene | Median expression | logFC | Adj p-value (FDR) | Mean beta value | Beta value difference | Adj p-value (FDR) | ||
|---|---|---|---|---|---|---|---|---|
Adult | Fetal | Adult | Fetal | |||||
DLK1 | 3.27 | 12.64 | 9.15 | 3.55E-46 | 0.42 | 0.63 | 0.22 | 3.19E-36 |
HBZ | 3.23 | 12.35 | 9.07 | 1.82E-45 | 0.8 | 0.55 | -0.25 | 4.02E-18 |
HBM | 3.01 | 12.52 | 9.03 | 4.27E-42 | 0.42 | 0.21 | -0.21 | 2.55E-11 |
AHSP | 4.37 | 13.26 | 8.46 | 2.66E-42 | 0.74 | 0.41 | -0.33 | 1.43E-34 |
EPB42 | 3.13 | 11.25 | 8.19 | 2.26E-48 | 0.89 | 0.47 | -0.42 | 3.84E-64 |
CYP2E1 | 13.42 | 4.1 | -7.64 | 8.63E-36 | 0.51 | 0.88 | 0.36 | 1.10E-41 |
HBE1 | 2.87 | 10.66 | 7.63 | 4.10E-48 | 0.76 | 0.49 | -0.27 | 1.41E-34 |
CRP | 13.33 | 4.33 | -7.27 | 7.71E-34 | 0.53 | 0.89 | 0.36 | 2.99E-42 |
C9 | 11.91 | 3.59 | -7.18 | 3.98E-39 | 0.48 | 0.84 | 0.36 | 8.73E-39 |
APCS | 12.69 | 4.39 | -7 | 5.95E-40 | 0.45 | 0.88 | 0.43 | 7.26E-48 |
SLC4A1 | 4.04 | 11.3 | 6.96 | 1.46E-61 | 0.75 | 0.4 | -0.35 | 2.14E-42 |
NNMT | 11.06 | 3.44 | -6.88 | 4.10E-40 | 0.36 | 0.84 | 0.48 | 7.10E-45 |
CYP2C8 | 12.9 | 4.83 | -6.85 | 3.42E-31 | 0.59 | 0.88 | 0.29 | 2.57E-36 |
AQP9 | 11.51 | 3.47 | -6.81 | 1.26E-33 | 0.39 | 0.84 | 0.45 | 8.23E-45 |
NFE2 | 4.1 | 11.03 | 6.8 | 2.29E-47 | 0.82 | 0.45 | -0.36 | 3.02E-41 |
ADH1C | 11.93 | 3.92 | -6.69 | 1.96E-24 | 0.42 | 0.81 | 0.39 | 8.06E-38 |
MYL4 | 3.88 | 10.77 | 6.65 | 6.78E-60 | 0.88 | 0.4 | -0.48 | 1.90E-62 |
C3P1 | 11.36 | 3.81 | -6.63 | 2.34E-37 | 0.73 | 0.24 | -0.49 | 1.56E-47 |
RHAG | 3.35 | 10.22 | 6.56 | 1.50E-46 | 0.81 | 0.49 | -0.31 | 1.64E-47 |
HSD17B6 | 12.12 | 4.61 | -6.31 | 4.88E-29 | 0.89 | 0.66 | -0.22 | 1.48E-41 |