Genetic and epigenetic regulation of gene expression in fetal and adult human livers

BMC Genomics

Table 4 Proportion of explained variation by SNPs and CpG sites associated with the expression of ADME genes

Gene/Locus	Chr	SNP	CpG site	% of variation in expression explained by
Gene/Locus	Chr	SNP	CpG site	SNP only	CpG only	SNP and CpG site	SNP and all CpG sites¹
GSTT1	22	rs9612520	cg05380919	50%	75%	78%	84%**
CYP3A5	7	CS015290	cg03133378	55%	7%	57%	57%
GSTM1	1	rs75953876	cg18938907	11%	55%	56%	61%
GPX7	1	rs11810754	cg11953272	48%	16%	49%	52%
UGT1A1	2	rs7592624	cg11811840	22%	41%	45%	47%
SLC22A18	11	rs413781	cg24724917	30%	15%	44%	49%*
FMO4	1	rs2223477	cg14981176	39%	16%	39%	39%
GSTM3	1	rs115636764	cg23645476	21%	20%	35%	46%**
SLC19A1	21	rs7867	cg27210852	22%	10%	30%	30%
GSTO2	10	rs11595547	cg23659134	20%	24%	28%	28%
PON1	7	rs854533	cg07404485	13%	23%	27%	30%
DHRS2	14	rs57350570	cg07125017	23%	4%	26%	26%
GSTA4	6	rs538920	cg22486834	14%	14%	20%	21%
CEBPA	19	rs80241821	cg19035908	17%	6%	20%	20%
MGST3	1	rs10737515	cg16553119	12%	12%	13%	13%
DHRS7	14	rs376391	cg18906360	12%	9%	13%	13%

*F-test p-value < 0.05; **F-test p-value < 0.005.
F-test null hypothesis: model for gene expression with the SNP and CpG site as explanatory variables and model for gene expression with the SNP and all CpG sites¹ fit equally well with the differences being due to random chance.
SNP and all CpG sites¹ - the CpG sites that have eQTM effects with the expression probe.

ISSN: 1471-2164