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Table 2 New accessory regions found in NT strains

From: Non-typeable pneumococci circulating in Portugal are of cps type NCC2 and have genomic features typical of encapsulated isolates

Accessory region

TIGR4 locus

Identified by STMa

Predicted functionb

42

SP_0115-0117

Yes

Cell envelope

43

SP_0124-0126

No

Hypothetical

44

SP_0130-0144

Yes

ABC transporter (glucose)

45

SP_0314-0330

Yes

PTS system

46

SP_0367-0369

No

Cell envelope

47

SP_0391-0393

No

Cell envelope

48

SP_0569-0571

Yes

Type II RM system

49

SP_0595-0597

Yes

Hypothetical

50

SP_0627-0629

No

Hypothetical

51

SP_0636-0640

No

ABC transporter

52

SP_0683-0685

No

Hypothetical

53

SP_0703-0711

No

ABC transporter (aa)

54

SP_0737-0740

No

Transport & transcription regulation

55

SP_1030-1040

Yes

ABC transporter (iron)

56

SP_1042-1045

Yes

Metabolic

57

SP_1119-1125

Yes

Metabolic (glycogen)

58

SP_1160-1165

No

Metabolic (acetoin)

59

SP_1209-1211

No

Hypothetical

60

SP_1656-1658

No

Hypothetical

61

SP_1677-1679

No

Hypothetical

62

SP_1849-1851

No

Type II RM system

63

SP_1855-1859

Yes

Transport & transcription regulation

64

SP_1869-1872

Yes

ABC transporter (iron)

65

SP_2147-2154

No

Metabolic (arginine)

66

SP_2178-2183

Yes

Hypothetical

  1. a – gene(s) within region(s) identified by signature-tagged mutagenesis as required for invasive disease [20]; b – ATP-binding cassette (ABC); phosphotransferase (PTS); restriction modification (RM); amino acid (aa).