Figure 5

DNA methylation alterations of transposable elements. (A) Percentage of DMRs overlapping transposable elements in EAC and UPSC. (B) DMR enrichment within transposable element subfamilies. Enrichments > 5-fold were shaded in red. (C) Epigenome browser view of five genomic copies of LTR6A and their methylation levels across multiple samples. Only MeDIP-seq signal tracks were included. Increased methylation levels were highlighted by pink shading. These elements were unmethylated in normal endometrium, differentially methylated across H1 ESC, PBMC, breast myoepithelial cells, and fetal brain, and hypermethylated in EAC and UPSC. (D) Epigenome browser view of five genomic copies of MER52A and their methylation levels across multiple samples. MeDIP-seq signal tracks were displayed. Decreased methylation levels were highlighted by green shading. These elements were methylated (normal endometrium, H1 ESC, PBMC, and fetal brain) or partially methylated (breast myoepithelial cells) in normal cells, but were hypomethylated in EAC and UPSC.