Common variants explain a large fraction of the variability in the liability to psoriasis in a Han Chinese population

Table 1 The comparative result of phenotypic variance explained by common variants

Type of data	No. of autosomal SNPs	No. of cases	No. of controls	h²_SNP(s.e.)	p value
G	494,641	1137	1123	33.2% (7.0%)	3 × 10^-6
G + I	5,610,687	1135	1116	34.9% (6.0%)	8 × 10^-9
HLA region in G + I	33,190	1135	1116	13.2% (2.0%)	<10^-9
Reported loci in G + I	77,919	1135	1116	14.1% (1.0%)	<10^-9

h²_SNP: Proportion of Variance in liability to psoriasis vulgaris explained by autosomal SNPs. s.e.: standard error.
Type of Data: G: All Genotyped; G + I: All Genotyped and Imputed; HLA region in G + I : All Genotyped and Imputed data in HLA region; Reported loci in G + I: 12 Reported loci data in Genotyped and Imputed data.

ISSN: 1471-2164