Table 2 Functional categories and number of genes found to be modified by morphine in each category

Signal transduction

311

152

ppp1r14ab, camk1γb, grb2, sept9a, itih3, ahnak, hrc, sesn3, megf6, btr22, tmem101, magi1b, vldlr*, hspb1*, plg*

159

LOC566752, a2ml, sh3bp5la, fam115, txndc9, tctex1d2, rcan2, rnf220b, hspb8, slc1a4*, wls*, grik‐l*

Energy metabolism

190

85

itih3, acox1, soat1, cyp17a2, cyp51, cox4.2, alpp, aldocb, pcmt*, plg*

105

aldh8a1, pklr, mpdu1b, mdh1b, phyhd1, hrasls, glb1l, glud1b*

Transcription

109

35

dcps, zbtb16, creb3l3*, junb*, dlx5a*, fos*, dlx4a*

74

sox19b, mettl11a, noc2l, dbx1b, junbb, her4.2, otpb*, sox11b*, sox21b*, hdac6*, dnmt3b*, sox19a*, sox11b*, mir429b

Protein modification and degradation

94

31

ube2d2, hspb1*, plg*

63

pcmt, rad23b, fbxo25, hspb8

Transport

90

43

slc31a1, abca12, apoea, abcb5, ctssb.2*, slc3a2*, abt4*, slc1a3a*, slc7a8*

47

a2ml, bcap31, aqp12, aqp3a, vamp5, slc1a4*, vamp4*, hiat1b*, apoIV*, brp44*, kctd12.2*

Neuronal function

95

36

bnip4, ppp1r14ab, acox1, serinc5, maptb, magi1b, hspb1*, plg*, aplp*, slc1a3a*, creb3l3*, hsp90a.1*, junba*, dlx5a*, fos*, glula

59

pcmt, dao.1, sox19b, a2ml, mettl11a, astn1, noc2l, copb2, dbx1b, junbb, her4.2, slc1a4*, her3*, wls*, grik‐like*, otpb*, cyrano*, sox11b*, sr*, sox21b*, glulb*, glud1b*, dnmt3b*, kctd12.2*, sox11b*, mir429b*

Development

80

36

bnip4, ppp1r14ab, camk1γb, acox1, ahnak, maptb, zbtb16, cyp11a1, magi1b, hspb1*, plg*, dlx5a*, dlx4a*

44

sox19b, a2ml, hspb8, noc2l, copb2, dbx1b, her4.2, her3*, wls*, otpb*, cyrano*, sox11b*, sox21b*, hoxb8a*, dnmt3b*, kctd12.2*, sox11b*

Cell structure and organization

56

27

mybpc2b, maptb, col5a1

29

mylz2, krt1‐19d

Apoptosis

42

19

bnip4, hspb1*, bbc3*

23

hspb8, noc2l, bcap31, casp9*, mir429b*

Cell cycle

31

15

sept9a, sesn3, ccnt1, hsp90a.1*, ccnd1*

16

ccnb3*

Immune response

30

12

ccl‐c11b, cxcl12a, ctssb.2*, plg*

18

crfb6

Amino acid and protein metabolism

28

11

hnmt, eif4a2, eif3hb, eif2c2, slc3a2*, slc7a8*

17

fah, dao.1, aldh18a1, iars, eif4g2b*, sr*, eif4g2a*, eif2s1l*

Replication

25

5

h1fx

20

rad23b, mettl11a, noc2l, h2afx*, dnmt3b*

Ribosomal

17

7

rpf2

10

nob1, fcf1

Response to chemical stimulus

9

3

hspb1*, hsp90a.1*

6

hspb8

Translation

8

2

gcn1l1

6

hbs1l*

Blood Coagulation

8

3

serping1

5

fgg

Stress

7

3

sesn3, hspb1*, hsp90a.1*

4

hspb8

Reproduction

4

3

1