From: Cohen’s h for detection of disease association with rare genetic variants
Chr | ES | SNP | Nearest gene or SNP | Location | MAF in controls | MAF in cases | OR | P-value | RD | P-value | Cohen’s h | P-value | Exact test P-valueb | Association of SNP or proxy with other cardiovascular phenotypes |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genes | within | associated | interval | |||||||||||
3 | All | rs17042882 | PLCL2 | 3p24.3 | 0.028 | 0.061 | 2.255 | 4.88 × 10-15 | 0.033 | 1.11 × 10-15 | 0.163 | 4.00 × 10-15 | --- | Heart failure, Arthritis |
3 | h | rs16827563 | VEPH1 | 3q24-q25 | 0.005 | 0 | NA | NA | -0.005 | 2.18 × 10-5 | -0.119 | 1.02 × 10-8 | 7.3 × 10-7 | Carotid artery disease, Diabetes Mellitus |
7 | RD | rs17146094 | EIF4H | 7q11.23 | 0.017 | 0.034 | 2.036 | 1.27 × 10-7 | 0.017 | 7.15 × 10-8 | 0.109 | 1.32 × 10-7 | --- | CAD |
8 | All | rs16891338 | SAMD12-AS1 | 8q24.12 | 0.023 | 0.043 | 1.908 | 4.11 × 10-8 | 0.02 | 2.50 × 10-8 | 0.113 | 4.66 × 10-8 | --- | Blood Pressure |
8 | All | rs16908145 | FLJ45872 | 8q24.23 | 0.022 | 0.043 | 1.998 | 6.54 × 10-9 | 0.021 | 3.46 × 10-9 | 0.12 | 7.08 × 10-9 | --- | |
15 | RD, h | rs7163007 | MAP2K5 | 15q23 | 0.002 | 0.011 | 5.551 | 2.13 × 10-7 | 0.009 | 5.33 × 10-9 | 0.121 | 5.85 × 10-9 | --- | BMI, Diabetes Mellitus |
16 | All | rs16955238 | GAN | 16q24.1 | 0.022 | 0.046 | 2.143 | 8.91 × 10-11 | 0.024 | 3.41 × 10-11 | 0.135 | 8.53 × 10-11 | --- | Cholesterol |
16 | h | rs7197337 | ANKRD26P1 | 16q11.2 | 0.006 | 0 | NA | NA | -0.006 | 2.88 × 10-6 | -0.132 | 1.76 × 10-10 | 2.3 × 10-8 | |
19 | All | rs11671119 | MEF2B MEF2NB | 19p13.11 | 0.033 | 0.071 | 2.239 | 0 | 0.038 | 0 | 0.174 | 0 | --- | Diabetes Mellitus |
SNPs near associated SNPs within 500 kb | ||||||||||||||
1 | RD, h | rs6674781 | rs6671793 | 2a | 0.002 | 0.011 | 5.55 | 2.13 × 10-7 | 0.009 | 5.33 × 10-9 | 0.121 | 5.85 × 10-9 | --- | Coronary disease |
3 | h | rs17064749 | rs7615788 | 10a | 0.008 | 0.001 | 0.124 | 8.36 × 10-5 | -0.007 | 2.84 × 10-6 | -0.116 | 2.28 × 10-8 | 4.2 × 10-7 | Cholesterol |
3 | h | rs10510375 | rs1450097 | 400a | 0.009 | 0.001 | 0.11 | 2.97 × 10-5 | -0.008 | 4.03 × 10-7 | -0.127 | 9.67 × 10-10 | 2.2 × 10-8 | Cholesterol, HDL |
3 | h | rs6805861 | rs10510197 | 250a | 0.007 | 0 | NA | NA | -0.007 | 3.84 × 10-7 | -0.145 | 2.92 × 10-12 | 1.2 × 10-9 | Cholesterol, HDL |
4 | All | rs890447 | rs97669522 | 25a | 0.043 | 0.078 | 1.883 | 6.49 × 10-13 | 0.035 | 3.09 × 10-13 | 0.148 | 8.35 × 10-13 | --- | CAD |
5 | All | rs159171 | rs10520872 | 500a | 0.025 | 0.055 | 2.27 | 6.88 × 10-14 | 0.03 | 1.62 × 10-14 | 0.156 | 5.51 × 10-14 | --- | Cholesterol, LDL |
5 | h | rs41349146 | rs2431337 | 500a | 0.007 | 0 | NA | NA | -0.007 | 3.84 × 10-7 | -0.145 | 2.92 × 10-12 | 1.2 × 10-9 | Arteries |
6 | h | rs41518850 | rs12190287 | 300a | 0.006 | 0 | NA | NA | -0.006 | 2.88 × 10-6 | -0.132 | 1.76 × 10-10 | 2.3 × 10-8 | CAD |
6 | h | rs4398751 | rs9397922 | 150a | 0.005 | 0 | NA | NA | -0.005 | 2.18 × 10-5 | -0.119 | 1.02 × 10-8 | 7.3 × 10-7 | Lipoprotein |
8 | All | rs16883114 | rs10503973 | 200a | 0.021 | 0.041 | 1.993 | 1.57 × 10-8 | 0.02 | 8.57 × 10-9 | 0.117 | 1.69 × 10-8 | --- | Cholesterol, LDL |
9 | RD, h | rs12343115 | rs2149998 | 300a | 0.009 | 0 | NA | NA | -0.009 | 6.97 × 10-9 | -0.167 | 6.66 × 10-16 | 3.6 × 10-12 | Myocardial Infarction |
18 | All | rs41477147 | rs10502528 | 150a | 0.028 | 0.065 | 2.413 | 0 | 0.037 | 0 | 0.179 | 0 | --- | Arteries |
(rs1595963) | ||||||||||||||
21 | h | rs7276641 | rs2829644 | 300a | 0.01 | 0.002 | 0.198 | 2.50 × 10-5 | -0.008 | 2.81 × 10-6 | -0.111 | 8.91 × 10-8 | --- | Coronary disease |