Figure 1From: Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in miceBaP–DNA adduct formation in 6 Balb/c mouse organs. The mice received 5 or 10 daily doses of 125 mg/kg b.wt/day BaP, or corn oil (control). (A) Autoradiographic profiles of DNA adducts obtained by TLC-32P-postlabelling. (B) Quantitative analysis of DNA adducts in mouse organs. Values represent the mean ± SD (n = 3). RAL; relative adduct labelling, adducts/108 nucleotides. Differences between males and females were not significant (p > 0.05). Differences between 5 and 10 days were significant (p < 0.05) except for lung (p = 0.06).Back to article page