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Figure 3 | BMC Genomics

Figure 3

From: Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

Figure 3

Gene association network (GAN) 3 in lung. The network was generated with 791 BaP-significantly modulated genes by Ingenuity Pathway Analysis (IPA). (A) shows 28 BaP-modulated genes. The gene-gene interactions reveal that NFκb can be regulated by 10 genes (Ecsit, Gpam, Ddost, Cops3, Birc4, Otud7b, Nedd4, Ube2, Btrc and Rnf7) and it may regulate other 3 genes (Fuca1, Cyb5r3 and Ccnd2). It also shows that core genes NFκb and Ube give central roles for the network functions protein synthesis and post-translational modification. Up-regulated genes are shown in red; down-regulated genes are shown in green. (B) the descriptions of interactions and transcriptional factors.

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