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Table 1 Genes significantly modulated by BaP in individual organs (Welch’s t-test, p < 0.05) for at least three conditions

From: Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

Probe

Symbol

Gene name

EntrezID

M1*

M2

M3

F1

F2

F3

Lung (target)

         

H3018D10

Actb

Actin, beta, cytoplasmic

11461

1.310

1.280

1.290

1.020

1.010

1.080

H3089D06

Cav

Caveolae protein 1

12389

2.350

2.270

2.260

1.500

1.730

1.660

H3110F10

Ephx1

Epoxide hydrolase 1, microsomal

13849

1.424

1.696

1.658

2.220

2.382

2.910

H3114C04

Giyd2

Giy-yig domain containing 2

75764

0.530

0.800

0.610

0.430

0.410

0.600

H3125H11

Hba-a1

Hemoglobin alpha, adult chain 1

15122

0.597

0.687

0.487

0.502

0.442

0.580

H3117D02

Hbb-y

Hemoglobin y, beta-like embryonic chain

15135

0.445

0.732

0.356

0.369

0.217

0.405

H3139E01

Hspa8

Heat shock protein 8

15481

1.687

2.068

1.994

2.060

1.954

1.625

H3097B08

Pdia3

Protein disulfide isomerase associated 3

14827

1.211

1.283

1.388

1.270

1.126

1.232

H3126C02

Rpl18

Ribosomal protein l18

19899

1.350

1.400

1.490

1.040

1.010

0.980

H3112G04

Rps5

Ribosomal protein s5

20103

1.310

1.290

1.350

0.970

0.860

1.000

H3068A11

Tmed5

Transmembrane emp24 protein transport domain containing 5

73130

1.270

1.310

1.330

1.320

1.120

1.270

Spleen (target)

        

H3077H03

Ccng1

Cyclin g1

12450

1.342

1.362

1.665

1.359

 

1.564

H3114C04

Giyd2

Giy-yig domain containing 2

75764

0.443

0.393

0.513

0.484

0.203

0.383

H3126A10

Hba-a1

Hemoglobin alpha, adult chain 1

15122

0.540

0.661

0.581

0.358

0.327

0.335

H3134E01

Hbb-y

Hemoglobin y, beta-like embryonic chain

15135

0.813

0.742

0.495

0.542

0.334

0.564

H3051C06

Hspa5

Heat shock 70kd protein 5

14828

1.061

1.359

1.433

1.047

1.241

1.522

H3139E01

Hspa8

Heat shock protein 8

15481

1.297

1.540

1.567

1.937

1.784

1.705

H3097B08

Pdia3

Protein disulfide isomerase associated 3

14827

1.126

1.224

1.388

1.161

1.204

1.425

H3130D03

Pip5k1c

Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

18717

0.330

0.340

0.420

0.640

0.470

0.530

H3139D02

Tubb5

Tubulin, beta 5

22154

0.649

0.650

0.716

0.744

0.619

0.725

Forestomach (target)

        

H3011E09

Actb

Actin, beta, cytoplasmic

11461

1.210

1.860

1.930

1.670

1.520

1.950

H3089D06

Cav

Caveolae protein 1

12389

 

0.570

0.630

0.570

0.910

0.700

H3126H01

Hba - a1

Hemoglobin alpha, adult chain 1

15122

0.210

0.240

0.150

0.510

0.470

0.300

H3051C06

Hspa5

Heat shock 70kd protein 5

14828

1.332

1.837

2.287

1.716

1.687

1.803

H3139E01

Hspa8

Heat shock protein 8

15481

1.570

2.382

2.752

1.674

1.956

2.153

H3130D03

Pip5k1c

Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

18717

0.520

0.550

0.740

0.590

0.560

0.790

H3126C02

Rpl18

Ribosomal protein l18

19899

1.510

1.370

1.640

0.950

1.030

1.160

H3112G02

Rps5

Ribosomal protein s5

20103

1.320

1.270

1.440

1.040

1.050

1.360

H3080H08

Tmed5

Transmembrane emp24 protein transport domain containing 5

73130

0.660

0.690

0.720

0.610

0.580

0.530

H3018E11

Tubb5

Tubulin, beta 5

22154

0.588

0.624

0.576

1.117

1.115

1.098

Liver (non-target)

        

H3133B06

Ccnd2

Cyclin d2

12444

1.757

2.639

1.519

1.724

1.532

1.924

H3125H11

Hba-a1

Hemoglobin alpha, adult chain 1

15122

0.170

0.420

0.490

0.490

0.280

0.290

H3139E01

Hspa8

Heat shock protein 8

15481

0.935

1.592

1.354

1.870

2.606

2.456

H3129E07

Rpl17

Ribosomal protein l17

319195

1.130

1.320

1.200

1.220

1.370

2.050

Colon (non-target)

        

H3139E01

Hspa8

Heat shock protein 8

15481

1.397

1.493

1.559

1.240

1.577

2.110

H3139D02

Tubb5

Tubulin, beta 5

22154

1.951

2.106

2.216

1.318

1.717

1.749

Glandular stomach (non-target)

       

H3089D06

Cav

Caveolae protein 1

12389

   

2.140

1.530

1.300

H3126H01

Hba-a1

Hemoglobin alpha, adult chain 1

15122

0.610

0.340

0.310

0.310

0.250

0.240

H3051C06

Hspa5

Heat shock 70kd protein 5

14828

1.316

1.780

1.294

1.253

1.661

1.165

H3029C06

Hspa8

Heat shock protein 8

15481

1.242

1.303

1.046

1.568

1.480

1.266

H3029F12

Rpl17

Ribosomal protein l17

319195

1.340

1.350

1.020

1.400

1.400

2.130

  1. *Columns M1, M2, M3, F1, F2 and F3 show the relative fold-change values in 6 exposure conditions (M1-male 125, M2-male 250, M3-male 375, F1-female 125, F2-female 250 and F3-female 375 mg/kg b.wt/day. Expression ratios in bold text mean being significant (p < 0.05) by Welch’s t-test. The genes shown in bold text were subsequently validated by Taqman gene expression assay.
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BMC Genomics

ISSN: 1471-2164

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