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Table 3 Some distinctive features of VAS as compared to some related tools

From: VAS: a convenient web portal for efficient integration of genomic features with millions of genetic variants

Tool

CADD [16]

GEMINI [18]

GWASdb [17]

GWAVA [19]

HaploReg [20]

RegulomeDB [12]

VAS

Client-side data compression

No

(local)

N/A

No

No

No

Yes

Input variants allowed

∼100,000

(Unlimited)

1

>10,000

10,000

∼5,000

3,000,000

Genomic features/aggregated

63

(User defined)

37

14

10

1,012

1,000+

features provided

  

(5 categories)

 

(6 categories)

(13 categories)

(16 categories)

Data storage and integration

(Not described)

Relational DB

Relational DB

(Not described)

Relational DB

Relational DB

Customized

Searching flanking regions

No

No

Yes

No

No

No

Yes

Asynchronous access of results

Yes

(local)

No

No

No

No

Yes

Linkout to genome browser

No

No

UCSC [24]

Ensembl [34]

No

UCSC

UCSC

  1. For GWAVA and RegulomeDB, the maximum number of input variants allowed is based on our own tests of the system. Properties of the tools are based on their versions on 8th September 2014.