Figure 1

Summary of fibroblast ChIP-seq results. A) Heatmap of RNA expression, H3K4me3, H3K9Ac, and H3K9me3 occupancy, and CpG Islands. Expression was determined using RNA-seq data from four male fibroblast cell lines. Green = expression or presence of element, Red = no expression or absence of element. White = no measurable expression or elements. B) Graph of percentage of genes that are expressed, percentage of promoters of expressed genes with indicated histone modifications or CpG island, and percentage of CpG islands marked by H3K4me3. K4me3 = H3K4me3; K9Ac = H3K9Ac; K9me3 = H3K9me3. C) and D) Histone profiles across an expressed gene (Abcd4) and a repressed gene (Saa). Blue bars = significant peak of enrichment within 5.5 kb of the putative promoter; green scans = marks of activation; red scans = marks of repression; black scans = input. Gaps (if present) and gene annotations are shown in the bottom panels.