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Table 1 Clinical data

From: Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease

Patient ID

No bone disease

Bisphosphonate tx (Y/N)

1 (D)

PET: no focal myelomatous lesions

Y

2 (D)

SS: No lytic lesions.

N

3 (D)

SS: no lytic lesions. Diffuse osteopenia.

N

4 (D)

SS: no evidence of lytic bone lesions

N

5 (D)

SS: no lytic disease

N

6 (D)

SS: no focal lytic lesions.

Y

7 (D)

SS and MRI spine: no lytic lesions

N

8 (D)

SS: no lytic lesions

Y

9 (D)

Notes: no evidence of bone disease on SS.

N

10 (D)

SS: no bone disease

N

11 (V)

SS: no lytic lesions identified.

N.

12 (V)

SS: no lytic lesions. MRI spine: no focal ltic lesions.

N

13 (V)

SS: no lytic lesions.

N

14 (V)

SS: no bone disease

N

15 (V)

Notes: SS negative for lytic bone disease.

N

16 (V)

SS and MRI spine: no lytic disease

N

17 (V)

SS: no lytic lesions.

N

18 (V)

SS: no lytic lesions

N

19 (V)

SS (x2): negative metastatic bone series.

n/a

20 (V)

SS: no lytic lesions or vert #s

N

21 (V)

SS: no evidence of lytic disease

N

22 (V)

SS: no lytic lesions

N

23 (V)

SS: no lytic lesions

Y

24 (V)

SS: no lytic lesions

N

25 (V)

SS: no lytic lesions

Y

26 (V)

SS: no lytic lesions.

N

27 (V)

SS: no dominant lytic lesion seen.

N

28 (V)

SS: no findings related to myeloma.

N

29 (V)

Notes: no lytic lesions SS

N

30 (V)

Notes (x2): no myeloma bone disease on SS.

N

31 (V)

Notes: no evidence of lytic bone disease (SS).

Y

32 (V)

SS: no evidence of lytic bone disease.

Y

33 (V)

SS and CT abdo/pelvis: no lytic lesions

Y

34 (V)

SS (x2): no lytic bone diesase.

Y

35 (V)

SS: no focal lucencies suggestive of myeloma.

n/a

36 (V)

SS: no lytic lesions

N

37 (V)

SS: no lytic lesions

Y

38 (V)

SS, CT spine and PET-CT: no lytic lesions.

N

39 (V)

SS: no lytic lesions

N

40 (V)

SS: no lytic disease

Y

41 (V)

SS: no lytic lesions

Y

Patient ID

High bone disease

Bisphosphonate tx (Y/N)

42 (D)

Lytic lesions in hip on MRI, and in thorax on CT.

N

43 (D)

Multiple lytic lesions, skull, pelvis, femur (SS)

Y

44 (D)

MRI: widespread bone disease, including extramedullary involvement.

Y

45 (D)

SS: multiple lucencies skull, pelcis, femora, compression #s spine.

n/a

46 (D)

SS: diffuse lytic disease

N

47 (D)

SS: C2 lesion and femoral neck lesions.

N

48 (D)

SS: multiple involving skull, humeri, femora.

Y

49 (D)

SS: multiple lucencies in the skull, and femoral lesion.

N

50 (D)

Notes: Multiple lytic bone lesions

Y

51 (D)

SS: multiple lytic lesions throughout skeleton.

Y

52 (V)

SS: lucencies invol. Ribs, scapulae, T/L spines.

N

53 (V)

Notes: multiple bony lesions with soft tissue extension.

n/a

54 (V)

MRI: multiple spinal lesions

Y

55 (V)

Notes: extensive bone involvement.

Y

56 (V)

SS: lucencies of skull, humerus, femur, pelvis.

N

57 (V)

SS: lesions of skull, ribs, humera, femur.

N

58 (V)

SS: multiple lucencies femurs, humeri, skull

Y

59 (V)

SS and MRI: skull, clavicle, vertebral lesions.

Y

60 (V)

Vertebral, femoral, extramedullary (lung) lesions.

N

61 (V)

SS: skull, humeri, vert lesions.

Y

62 (V)

PET-CT: increased uptake left ilial and T12 vert, rib #s

N

63 (V)

MRI: multiple compression #s spine, sacral lesions

Y

64 (V)

SS: multiple lucencies, skull, humeri, femurs.

n/a

65 (V)

SS: femurs, pelvis, skull luc, compressn # T9

Y

66 (V)

CT: lumbar spine, rib, pelvis, sternal lesions

Y

67 (V)

MRI: multiple vertebral lesions

Y

68 (V)

SS: lesions skull, pelvis, femora.

Y

69 (V)

SS: skull, humrea, vert lesions

n/a

70 (V)

Notes: scapular, pelvic and hip lesions.

Y

71 (V)

SS: skull, vert, humeri lucencies

N

72 (V)

SS/MRI: multiple lesions pelvis and lt humerus.

Y

73 (V)

SS/MRIs: lumbar, thoracic and sacral lesions.

Y

74 (V)

SS/PET: skull lesions and sternal plasmacytoma

N

75 (V)

SS: lucencies femora, skull, humerus.

N

76 (V)

SS: diffuse myel. involve. (skull, hum, fem, t spine, skull).

Y

77 (V)

Notes: lucencies C/T spine and scapula.

N

78 (V)

Notes: destructive lesions L2 and acetabulum.

Y

79 (V)

SS: compressn #s spine, lucencies skull, femora, humeri.

Y

80 (V)

PETCT: diffuse uptake spine, sternum, femora.

N

81 (V)

MRI: T7-9 lesions with cord compression

N

82 (V)

SS: lucencies femora, skull, humeri.

Y

83 (V)

SS: lucencies of skull, clavicles, humera, T spine.

Y

84 (V)

CT: 2 rib #s and compressn # T5

N

85 (V)

CT: innumerable lesions within axial and appendicular skeleton.

N

86 (V)

SS: lucencies in vert, pelvis, humeri, femora.

N

87 (V)

SS: lesions in skull, ribs, T spine, humeri.

Y

88 (V)

SS: multiple lesions skull, pelvis, and T12 compressn #.

n/a

89 (V)

Notes: review of outside films demonstrates extensive bony disease

N

90 (V)

SS: Numerous lesions in skull and extremeties.

N

Patient ID

Pre-malignant myeloma

Bisphosphonate tx (Y/N)

91 (V)

MGUS

N

92 (V)

MGUS

N

93 (V)

MGUS

N

94 (V)

MGUS

N

95 (V)

MGUS

N

96 (V)

MGUS

N

97 (V)

MGUS

N

98 (V)

MGUS

N

99 (V)

MGUS

N

100 (V)

SMM

N

101 (V)

SMM

N

102 (V)

SMM

N

103 (V)

SMM

N

104 (V)

SMM

N

105 (V)

SMM

N

106 (V)

SMM

N

107 (V)

SMM

N

108 (V)

SMM

N

109 (V)

SMM

N

110 (V)

SMM

N

111 (V)

SMM

N

  1. Clinical data for the 111 patient samples used in this study. 41 patients diagnosed with no bone disease, 49 patients with high bone disease and 21 patients with monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM). Samples are labeled with (D) for discovery and (V) for validation, indicating the phase in which they were used. Information on whether the patients were on bisphosphonate treatment (tx) at the time the sample was taken is included (Y = yes, N = no). n/a = not available.