KEGG pathway | Gene set size | Observed hits | Adjusted p-value* | Hits (Gene_Symbols) |
---|---|---|---|---|
mTOR signaling pathway (hsa04150) | 52 | 27 | 0.0000505 | AKT1, AKT3, CAB39, CAB39L, EIF4E2, EIF4EBP1, MAPK1M MAPK3, MLST8, MTOR, PIK3CB, PIK3R2, PRKAA1, PRKAA1, RHEB, RPS6, RPS6KA2, RPS6KA3, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK3, VEGFA, VEGFB, VEGFC |
ErbB signaling pathway (hsa04012) | 87 | 35 | 0.0019942 | ABL1, AKT1, AKT3, BAD, CDKN1A, CDKN1B, CRK, CRKL, EGFR, EIF4EBP1, ELK1, ERBB2, GRN2, GSK3B, HBEGF, HRAS, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK3, MAPK8, MAPK9, MTOR, MYC, NCK2, NRAS, PAK1, PAK2, PIK3CB, PIK3RS, RPS6KB1, RPS6KB2 |
TGF-beta signaling pathway (hsa04330) | 83 | 33 | 0.0032629 | BMPR1A, BMPR2, CDKN2B, CUL1, E2F4, ID1, ID3, MAPK1, MAPK3, MYC, PPP2CB, PPP2R1A, PPP2R1B, RBL2, RBX1, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMADA, SMAD4, SMAD7, SMURF2, SP1, TFDP1, TGFB2, TGFBR1, TGFBR2, THBS2, ZFYVE16, ZFYVE9 |
Notch signaling pathway (hsa04330) | 46 | 20 | 0.0056174 | ADAM17, APH1A, CIR1, CTBP1, CTBP1, CTBP2, DTX3, DTX3, DTX3L, DVL1, DVL2, HDAC1, HDAC1, HDAC2, HES1, NCOR2, NOTCH2, NOTCH3, NUMB, NUMBL, PSEN2, RBPJ, RFNG |
Osteociast differentiation (hsa04380) | 127 | 45 | 0.0088651 | AKT1, AKT3, CHUK, CYBA, FHL2, FOS, FOSB, FOSB, FOSL1, FOSL2, GRB2, IFNAR1, IFNAR2, IFNGR1, IFNGR2, IFNGR2, IKBKB, IRF9, JAK1, JUNB, JUND, MAP2K1, MAP2K7, MAP2K7, MAP3K7, MAPK1, MAPK12, MAPK14, MAPK3, MAPK3, MAPK8, MAPK9, NFKBIA, PIK3CB, PIK3R2, PP3CA, PPP3CC, RAC1, RELA, SIRPA, SOCS3, SQSTM1, STAT2, TAB2, TGFB2, TGFBRI, TGFBR2, TNFRSF11B, TYK2 |
Wnt signaling pathway (hsa04310) | 150 | 51 | 0.0134525 | CCND1, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, DVL1, DVL2, FOSL1, FZD2, FZD4, FZD6, FZD7, FZD8, GSK3B, LRP5, LRP6, MAP3K7, MAPK8, MAPK9, MYC, PLCB3, PPP2R5C, PPP2RSE, PPP3CA, PPP3CC, PPP3R1, PRICKLE1, SENP2, SFRP4, SIAH1, SKP1, SMAD2, SMAD4, TCF7L1, WNT5B |
Apoptosis (hsa04210) | 87 | 32 | 0.0136314 | AIFM1, AKT1, AKT3, BAD, BAX, BCL2L1, BID, BIRC2, CAPN1, CAPN2, CASP6, CASP8, CAPSP9, CFLAR, CHUK, ENDOG, FADD, IKBKB, IRAK1, NFKBIA, PIK3CB, PIK3R2, PPP3CA, PPP3CC, PPP3R1, PRKACA, PRKAR1A, RELA, RIPK1, TNFRSF10D, TRADD, XDIAP |
VEGF signaling pathway (hsa04370) | 75 | 28 | 0.0160140 | AKT1, AKT3, BAD, CASP9, CDC42, HRAS, HSPB1, KRAS, |
Adipocytokine signaling pathway (hsa04920) | 67 | 25 | 0.0207573 | ACSL1, ACSL3, ADIPOR1, ADIPOR2, AKT1, AKT3, CHUK, CPT1A, IKBKB, MAPK8, MAPK9, MAPK9, MTOR, NFKBIA, NFKBIB, PCK2, PRKAA1, PRKAB1, PRLAB2, PRKAG1, PTPN11, RELA, SOCS3, STAT3, STK11, TRADD |